The mucosal immune system and IgA nephropathy

The precise pathogenesis of immunoglobulin A nephropathy (IgAN) is still not clearly established but emerging evidence confirms a pivotal role for mucosal immunity. This review focuses on the key role of mucosa-associated lymphoid tissue (MALT) in promoting the onset of the disease, underlying the r...

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Detalles Bibliográficos
Autores principales: Gesualdo, Loreto, Di Leo, Vincenzo, Coppo, Rosanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8551125/
https://www.ncbi.nlm.nih.gov/pubmed/34642783
http://dx.doi.org/10.1007/s00281-021-00871-y
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author Gesualdo, Loreto
Di Leo, Vincenzo
Coppo, Rosanna
author_facet Gesualdo, Loreto
Di Leo, Vincenzo
Coppo, Rosanna
author_sort Gesualdo, Loreto
collection PubMed
description The precise pathogenesis of immunoglobulin A nephropathy (IgAN) is still not clearly established but emerging evidence confirms a pivotal role for mucosal immunity. This review focuses on the key role of mucosa-associated lymphoid tissue (MALT) in promoting the onset of the disease, underlying the relationship among microbiota, genetic factors, food antigen, infections, and mucosal immune response. Finally, we evaluate potential therapies targeting microbes and mucosa hyperresponsiveness in IgAN patients.
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spelling pubmed-85511252021-10-29 The mucosal immune system and IgA nephropathy Gesualdo, Loreto Di Leo, Vincenzo Coppo, Rosanna Semin Immunopathol Review The precise pathogenesis of immunoglobulin A nephropathy (IgAN) is still not clearly established but emerging evidence confirms a pivotal role for mucosal immunity. This review focuses on the key role of mucosa-associated lymphoid tissue (MALT) in promoting the onset of the disease, underlying the relationship among microbiota, genetic factors, food antigen, infections, and mucosal immune response. Finally, we evaluate potential therapies targeting microbes and mucosa hyperresponsiveness in IgAN patients. Springer Berlin Heidelberg 2021-10-12 2021 /pmc/articles/PMC8551125/ /pubmed/34642783 http://dx.doi.org/10.1007/s00281-021-00871-y Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review
Gesualdo, Loreto
Di Leo, Vincenzo
Coppo, Rosanna
The mucosal immune system and IgA nephropathy
title The mucosal immune system and IgA nephropathy
title_full The mucosal immune system and IgA nephropathy
title_fullStr The mucosal immune system and IgA nephropathy
title_full_unstemmed The mucosal immune system and IgA nephropathy
title_short The mucosal immune system and IgA nephropathy
title_sort mucosal immune system and iga nephropathy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8551125/
https://www.ncbi.nlm.nih.gov/pubmed/34642783
http://dx.doi.org/10.1007/s00281-021-00871-y
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