Structure of PDE3A–SLFN12 complex and structure-based design for a potent apoptosis inducer of tumor cells

Molecular glues are a class of small molecular drugs that mediate protein-protein interactions, that induce either the degradation or stabilization of target protein. A structurally diverse group of chemicals, including 17-β-estradiol (E2), anagrelide, nauclefine, and DNMDP, induces apoptosis by for...

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Detalles Bibliográficos
Autores principales: Chen, Jie, Liu, Nan, Huang, Yinpin, Wang, Yuanxun, Sun, Yuxing, Wu, Qingcui, Li, Dianrong, Gao, Shuanhu, Wang, Hong-Wei, Huang, Niu, Qi, Xiangbing, Wang, Xiaodong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8551160/
https://www.ncbi.nlm.nih.gov/pubmed/34707099
http://dx.doi.org/10.1038/s41467-021-26546-8

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