The c-Rel transcription factor limits early interferon and neuroinflammatory responses to prevent herpes simplex encephalitis onset in mice

Herpes simplex virus type 1 (HSV-1) is the predominant cause of herpes simplex encephalitis (HSE), a condition characterized by acute inflammation and viral replication in the brain. Host genetics contribute to HSE onset, including monogenic defects in type I interferon signaling in cases of childho...

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Detalles Bibliográficos
Autores principales: Mancini, Mathieu, Charbonneau, Benoît, Langlais, David, Vidal, Silvia M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8551191/
https://www.ncbi.nlm.nih.gov/pubmed/34707143
http://dx.doi.org/10.1038/s41598-021-00391-7

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