Optineurin modulates the maturation of dendritic cells to regulate autoimmunity through JAK2-STAT3 signaling

Optineurin (OPTN) has important functions in diverse biological processes and diseases, but its effect on dendritic cell (DC) differentiation and functionality remains elusive. Here we show that OPTN is upregulated in human and mouse DC maturation, and that deletion of Optn in mice via CD11c-Cre att...

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Detalles Bibliográficos
Autores principales: Wang, Jiajia, Wang, Jiaying, Hong, Wenxiang, Zhang, Lulu, Song, Liqian, Shi, Qi, Shao, Yanfei, Hao, Guifeng, Fang, Chunyan, Qiu, Yueping, Yang, Lijun, Yang, Zhaoxu, Wang, Jincheng, Cao, Ji, Yang, Bo, He, Qiaojun, Weng, Qinjie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8551263/
https://www.ncbi.nlm.nih.gov/pubmed/34707127
http://dx.doi.org/10.1038/s41467-021-26477-4

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