The effect of fatty diacid acylation of human PYY(3-36) on Y(2) receptor potency and half-life in minipigs

Peptides are notoriously known to display very short in vivo half-lives often measured in minutes which in many cases greatly reduces or eliminates sufficient in vivo efficacy. To obtain long half-lives allowing for up to once-weekly dosing regimen, fatty acid acylation (lipidation) have been used t...

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Detalles Bibliográficos
Autores principales: Østergaard, Søren, Paulsson, Johan F., Kofoed, Jacob, Zosel, Franziska, Olsen, Jørgen, Jeppesen, Claus Bekker, Spetzler, Jane, Ynddal, Lars, Schleiss, Luise Gram, Christoffersen, Berit Østergaard, Raun, Kirsten, Sensfuss, Ulrich, Nielsen, Flemming Seier, Jørgensen, Rasmus, Wulff, Birgitte S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8551270/
https://www.ncbi.nlm.nih.gov/pubmed/34707178
http://dx.doi.org/10.1038/s41598-021-00654-3

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