Cargando…

Structure dynamics of HIV-1 Env trimers on native virions engaged with living T cells

The HIV-1 envelope glycoprotein (Env) mediates viral entry into the host cell. Although the highly dynamic nature of Env intramolecular conformations has been shown with single molecule spectroscopy in vitro, the bona fide Env intra- and intermolecular mechanics when engaged with live T cells remain...

Descripción completa

Detalles Bibliográficos
Autores principales:	Carlon-Andres, Irene, Malinauskas, Tomas, Padilla-Parra, Sergi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8551276/ https://www.ncbi.nlm.nih.gov/pubmed/34707229 http://dx.doi.org/10.1038/s42003-021-02658-1

Ejemplares similares

Site-Specific Glycosylation of Virion-Derived HIV-1 Env Is Mimicked by a Soluble Trimeric Immunogen
por: Struwe, Weston B., et al.
Publicado: (2018)

Quantitative FRET-FLIM-BlaM to Assess the Extent of HIV-1 Fusion in Live Cells
por: Carlon-Andres, Irene, et al.
Publicado: (2020)

Native‐like Env trimers as a platform for HIV‐1 vaccine design
por: Sanders, Rogier W., et al.
Publicado: (2017)

HIV-1 Env trimers asymmetrically engage CD4 receptors in membranes
por: Li, Wenwei, et al.
Publicado: (2023)

Structure of a cleavage-independent HIV Env recapitulates the glycoprotein architecture of the native cleaved trimer
por: Sarkar, Anita, et al.
Publicado: (2018)

Structure and immune recognition of trimeric prefusion HIV-1 Env
por: Pancera, Marie, et al.
Publicado: (2014)

Differential binding of neutralizing and non-neutralizing antibodies to native-like soluble HIV-1 Env trimers, uncleaved Env proteins, and monomeric subunits
por: Yasmeen, Anila, et al.
Publicado: (2014)

Reducing V3 Antigenicity and Immunogenicity on Soluble, Native-Like HIV-1 Env SOSIP Trimers
por: Ringe, Rajesh P., et al.
Publicado: (2017)

Crystal structures of trimeric HIV Env with entry inhibitors BMS-378806 and BMS-626529
por: Pancera, Marie, et al.
Publicado: (2017)

Trimeric HIV Env provides epitope occlusion mediated by hypervariable loops
por: Moscoso, Carlos G., et al.
Publicado: (2014)

Retroviral Env Glycoprotein Trafficking and Incorporation into Virions
por: Murakami, Tsutomu
Publicado: (2012)

Viral vector delivery of Env trimer immunogens
por: Parks, CL, et al.
Publicado: (2012)

Imaging real-time HIV-1 virion fusion with FRET-based biosensors
por: Jones, Daniel M., et al.
Publicado: (2015)

Antibody Recognition of CD4-Induced Open HIV-1 Env Trimers
por: Yang, Zhi, et al.
Publicado: (2022)

Cryo-ET of Env on intact HIV virions reveals structural variation and positioning on the Gag lattice
por: Mangala Prasad, Vidya, et al.
Publicado: (2022)

Structures and immune recognition of Env trimers from two Asia prevalent HIV-1 CRFs
por: Niu, Jun, et al.
Publicado: (2023)

Receptor Activation of HIV-1 Env Leads to Asymmetric Exposure of the gp41 Trimer
por: Khasnis, Mukta D., et al.
Publicado: (2016)

Immunogenicity of stabilized HIV-1 Env trimers delivered by self-amplifying mRNA
por: Aldon, Yoann, et al.
Publicado: (2021)

Fusion of the molecular adjuvant C3d to cleavage-independent native-like HIV-1 Env trimers improves the elicited antibody response
por: Bale, Shridhar, et al.
Publicado: (2023)

Design of lipid nanoparticle delivery agents for multivalent display of recombinant Env trimers in HIV vaccination
por: Pejawar-Gaddy, S, et al.
Publicado: (2012)

Design of Lipid Nanocapsule Delivery Vehicles for Multivalent Display of Recombinant Env Trimers in HIV Vaccination
por: Pejawar-Gaddy, Sharmila, et al.
Publicado: (2014)

Glutaraldehyde Cross-linking of HIV-1 Env Trimers Skews the Antibody Subclass Response in Mice
por: Soldemo, Martina, et al.
Publicado: (2017)

Mapping Neutralizing Antibody Epitope Specificities to an HIV Env Trimer in Immunized and in Infected Rhesus Macaques
por: Zhao, Fangzhu, et al.
Publicado: (2020)

Structural and functional evaluation of de novo-designed, two-component nanoparticle carriers for HIV Env trimer immunogens
por: Antanasijevic, Aleksandar, et al.
Publicado: (2020)

Neutralizing antibodies elicited in rabbits by patient-derived Env trimer immunization
por: Heyndrickx, L, et al.
Publicado: (2012)

Selected HIV-1 Env Trimeric Formulations Act as Potent Immunogens in a Rabbit Vaccination Model
por: Heyndrickx, Leo, et al.
Publicado: (2013)

High-resolution mapping of the neutralizing and binding specificities of polyclonal sera post-HIV Env trimer vaccination
por: Dingens, Adam S, et al.
Publicado: (2021)

Interactions of peptide triazole thiols with Env gp120 induce irreversible breakdown and inactivation of HIV-1 virions
por: Bastian, Arangassery Rosemary, et al.
Publicado: (2013)

Soluble HIV-1 Env trimers in adjuvant elicit potent and diverse functional B cell responses in primates
por: Sundling, Christopher, et al.
Publicado: (2010)

Soluble HIV-1 Env trimers in adjuvant elicit potent and diverse functional B cell responses in primates
por: Sundling, Christopher, et al.
Publicado: (2010)

HIV-1 Env trimer opens through an asymmetric intermediate in which individual protomers adopt distinct conformations
por: Ma, Xiaochu, et al.
Publicado: (2018)

Multicolor lifetime imaging and its application to HIV-1 uptake
por: Starling, Tobias, et al.
Publicado: (2023)

Structurally related but genetically unrelated antibody lineages converge on an immunodominant HIV-1 Env neutralizing determinant following trimer immunization
por: Aljedani, Safia S., et al.
Publicado: (2021)

Native Morphology of Influenza Virions
por: Noda, Takeshi
Publicado: (2012)

Similarities and differences between native HIV-1 envelope glycoprotein trimers and stabilized soluble trimer mimetics
por: Torrents de la Peña, Alba, et al.
Publicado: (2019)

Virion Background and Efficiency of Virion Incorporation Determine Susceptibility of Simian Immunodeficiency Virus Env-Driven Viral Entry to Inhibition by IFITM Proteins
por: Wrensch, Florian, et al.
Publicado: (2017)

Complementation of diverse HIV-1 Env defects through cooperative subunit interactions: a general property of the functional trimer
por: Salzwedel, Karl, et al.
Publicado: (2009)

Immunofocusing and enhancing autologous Tier-2 HIV-1 neutralization by displaying Env trimers on two-component protein nanoparticles
por: Brouwer, Philip J. M., et al.
Publicado: (2021)

Antigenic and 3D structural characterization of soluble X4 and hybrid X4-R5 HIV-1 Env trimers
por: Arnold, Philipp, et al.
Publicado: (2014)

Structure-Guided Redesign Improves NFL HIV Env Trimer Integrity and Identifies an Inter-Protomer Disulfide Permitting Post-Expression Cleavage
por: Yang, Lifei, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_9jg8eco53uqt3nk92qtpaj7ajm