c-Myc-activated USP2-AS1 suppresses senescence and promotes tumor progression via stabilization of E2F1 mRNA

The c-Myc oncoprotein plays a prominent role in cancer initiation, progression, and maintenance. Long noncoding RNAs (lncRNAs) are recently emerging as critical regulators of the c-Myc signaling pathway. Here, we report the lncRNA USP2-AS1 as a direct transcriptional target of c-Myc. Functionally, U...

Descripción completa

Detalles Bibliográficos
Autores principales: Li, Bingyan, Zhang, Guang, Wang, Zhongyu, Yang, Yang, Wang, Chenfeng, Fang, Debao, Liu, Kaiyue, Wang, Fang, Mei, Yide
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8551278/
https://www.ncbi.nlm.nih.gov/pubmed/34707111
http://dx.doi.org/10.1038/s41419-021-04330-2

Ejemplares similares

Ejemplares similares