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Adequate magnesium level as an associated factor of pre-diabetes and diabetes mellitus remission in patients with obesity submitted to bariatric surgery

Bariatric surgery (BS) can lead to remission of type 2 diabetes mellitus (T2DM), however, the evidence on the influence of preoperative serum magnesium levels on this reversal is scarce. To study the influence of preoperative serum magnesium levels on the pre-T2DM and T2DM remission one year after B...

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Autores principales: Guerreiro, Vanessa, Maia, Isabel, Neves, João Sérgio, Salazar, Daniela, Ferreira, Maria João, Mendonça, Fernando, Silva, Maria Manuel, Viana, Sara, Costa, Cláudia, Pedro, Jorge, Varela, Ana, Lau, Eva, Freitas, Paula, Carvalho, Davide
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8551299/
https://www.ncbi.nlm.nih.gov/pubmed/34707130
http://dx.doi.org/10.1038/s41598-021-00584-0
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author Guerreiro, Vanessa
Maia, Isabel
Neves, João Sérgio
Salazar, Daniela
Ferreira, Maria João
Mendonça, Fernando
Silva, Maria Manuel
Viana, Sara
Costa, Cláudia
Pedro, Jorge
Varela, Ana
Lau, Eva
Freitas, Paula
Carvalho, Davide
author_facet Guerreiro, Vanessa
Maia, Isabel
Neves, João Sérgio
Salazar, Daniela
Ferreira, Maria João
Mendonça, Fernando
Silva, Maria Manuel
Viana, Sara
Costa, Cláudia
Pedro, Jorge
Varela, Ana
Lau, Eva
Freitas, Paula
Carvalho, Davide
author_sort Guerreiro, Vanessa
collection PubMed
description Bariatric surgery (BS) can lead to remission of type 2 diabetes mellitus (T2DM), however, the evidence on the influence of preoperative serum magnesium levels on this reversal is scarce. To study the influence of preoperative serum magnesium levels on the pre-T2DM and T2DM remission one year after BS. Retrospective study carried out among 1656 patients with obesity who underwent BS in the Centro Hospitalar Universitário São João. T2DM and pre-T2DM remission were defined as being normal glycaemic measures of at least one year’s after BS and without pharmacological therapy. To assess the association between preoperative serum magnesium levels and pre- and T2DM remission, logistic regression models, crude and adjusted for sex, age and body mass index were computed. Patients with normoglycaemia presented hypomagnesaemia less often than those patients with pre-T2DM and T2DM (17.0% vs. 21.3% vs. 39.9%) (p < 0.001). One year after BS, 62.9% of patients with pre-T2DM or T2DM before BS showed remission. Adequate magnesium levels were positively associated with T2DM and pre-T2DM remission, one year after BS (OR 1.79; 95% CI 1.34–2.38), independently of sex, age, and body mass index. Adequate preoperative serum magnesium levels showed to be an important clinical parameter for pre-T2DM and T2DM remission.
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spelling pubmed-85512992021-11-01 Adequate magnesium level as an associated factor of pre-diabetes and diabetes mellitus remission in patients with obesity submitted to bariatric surgery Guerreiro, Vanessa Maia, Isabel Neves, João Sérgio Salazar, Daniela Ferreira, Maria João Mendonça, Fernando Silva, Maria Manuel Viana, Sara Costa, Cláudia Pedro, Jorge Varela, Ana Lau, Eva Freitas, Paula Carvalho, Davide Sci Rep Article Bariatric surgery (BS) can lead to remission of type 2 diabetes mellitus (T2DM), however, the evidence on the influence of preoperative serum magnesium levels on this reversal is scarce. To study the influence of preoperative serum magnesium levels on the pre-T2DM and T2DM remission one year after BS. Retrospective study carried out among 1656 patients with obesity who underwent BS in the Centro Hospitalar Universitário São João. T2DM and pre-T2DM remission were defined as being normal glycaemic measures of at least one year’s after BS and without pharmacological therapy. To assess the association between preoperative serum magnesium levels and pre- and T2DM remission, logistic regression models, crude and adjusted for sex, age and body mass index were computed. Patients with normoglycaemia presented hypomagnesaemia less often than those patients with pre-T2DM and T2DM (17.0% vs. 21.3% vs. 39.9%) (p < 0.001). One year after BS, 62.9% of patients with pre-T2DM or T2DM before BS showed remission. Adequate magnesium levels were positively associated with T2DM and pre-T2DM remission, one year after BS (OR 1.79; 95% CI 1.34–2.38), independently of sex, age, and body mass index. Adequate preoperative serum magnesium levels showed to be an important clinical parameter for pre-T2DM and T2DM remission. Nature Publishing Group UK 2021-10-27 /pmc/articles/PMC8551299/ /pubmed/34707130 http://dx.doi.org/10.1038/s41598-021-00584-0 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Guerreiro, Vanessa
Maia, Isabel
Neves, João Sérgio
Salazar, Daniela
Ferreira, Maria João
Mendonça, Fernando
Silva, Maria Manuel
Viana, Sara
Costa, Cláudia
Pedro, Jorge
Varela, Ana
Lau, Eva
Freitas, Paula
Carvalho, Davide
Adequate magnesium level as an associated factor of pre-diabetes and diabetes mellitus remission in patients with obesity submitted to bariatric surgery
title Adequate magnesium level as an associated factor of pre-diabetes and diabetes mellitus remission in patients with obesity submitted to bariatric surgery
title_full Adequate magnesium level as an associated factor of pre-diabetes and diabetes mellitus remission in patients with obesity submitted to bariatric surgery
title_fullStr Adequate magnesium level as an associated factor of pre-diabetes and diabetes mellitus remission in patients with obesity submitted to bariatric surgery
title_full_unstemmed Adequate magnesium level as an associated factor of pre-diabetes and diabetes mellitus remission in patients with obesity submitted to bariatric surgery
title_short Adequate magnesium level as an associated factor of pre-diabetes and diabetes mellitus remission in patients with obesity submitted to bariatric surgery
title_sort adequate magnesium level as an associated factor of pre-diabetes and diabetes mellitus remission in patients with obesity submitted to bariatric surgery
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8551299/
https://www.ncbi.nlm.nih.gov/pubmed/34707130
http://dx.doi.org/10.1038/s41598-021-00584-0
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