Lung mesenchymal stromal cells influenced by Th2 cytokines mobilize neutrophils and facilitate metastasis by producing complement C3

Pre-metastatic niche formation is critical for the colonization of disseminated cancer cells in distant organs. Here we find that lung mesenchymal stromal cells (LMSCs) at pre-metastatic stage possess potent metastasis-promoting activity. RNA-seq reveals an upregulation of complement 3 (C3) in those...

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Detalles Bibliográficos
Autores principales: Zheng, Zhiyuan, Li, Ya-nan, Jia, Shanfen, Zhu, Mengting, Cao, Lijuan, Tao, Min, Jiang, Jingting, Zhan, Shenghua, Chen, Yongjing, Gao, Ping-Jin, Hu, Weiguo, Wang, Ying, Shao, Changshun, Shi, Yufang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8551331/
https://www.ncbi.nlm.nih.gov/pubmed/34707103
http://dx.doi.org/10.1038/s41467-021-26460-z

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