A non-canonical, interferon-independent signaling activity of cGAMP triggers DNA damage response signaling

Cyclic guanosine monophosphate-adenosine monophosphate (cGAMP), produced by cyclic GMP-AMP synthase (cGAS), stimulates the production of type I interferons (IFN). Here we show that cGAMP activates DNA damage response (DDR) signaling independently of its canonical IFN pathways. Loss of cGAS dampens D...

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Detalles Bibliográficos
Autores principales: Banerjee, Daipayan, Langberg, Kurt, Abbas, Salar, Odermatt, Eric, Yerramothu, Praveen, Volaric, Martin, Reidenbach, Matthew A., Krentz, Kathy J., Rubinstein, C. Dustin, Brautigan, David L., Abbas, Tarek, Gelfand, Bradley D., Ambati, Jayakrishna, Kerur, Nagaraj
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8551335/
https://www.ncbi.nlm.nih.gov/pubmed/34707113
http://dx.doi.org/10.1038/s41467-021-26240-9

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