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DNA Mutations via Chern–Simons Currents
We test the validity of a possible schematization of DNA structure and dynamics based on the Chern–Simons theory, that is a topological field theory mostly considered in the context of effective gravity theories. By means of the expectation value of the Wilson Loop, derived from this analogue gravit...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8551353/ https://www.ncbi.nlm.nih.gov/pubmed/34725629 http://dx.doi.org/10.1140/epjp/s13360-021-01960-5 |
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author | Bajardi, Francesco Altucci, Lucia Benedetti, Rosaria Capozziello, Salvatore Sorbo, Maria Rosaria Del Franci, Gianluigi Altucci, Carlo |
author_facet | Bajardi, Francesco Altucci, Lucia Benedetti, Rosaria Capozziello, Salvatore Sorbo, Maria Rosaria Del Franci, Gianluigi Altucci, Carlo |
author_sort | Bajardi, Francesco |
collection | PubMed |
description | We test the validity of a possible schematization of DNA structure and dynamics based on the Chern–Simons theory, that is a topological field theory mostly considered in the context of effective gravity theories. By means of the expectation value of the Wilson Loop, derived from this analogue gravity approach, we find the point-like curvature of genomic strings in KRAS human gene and COVID-19 sequences, correlating this curvature with the genetic mutations. The point-like curvature profile, obtained by means of the Chern–Simons currents, can be used to infer the position of the given mutations within the genetic string. Generally, mutations take place in the highest Chern–Simons current gradient locations and subsequent mutated sequences appear to have a smoother curvature than the initial ones, in agreement with a free energy minimization argument. |
format | Online Article Text |
id | pubmed-8551353 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-85513532021-10-28 DNA Mutations via Chern–Simons Currents Bajardi, Francesco Altucci, Lucia Benedetti, Rosaria Capozziello, Salvatore Sorbo, Maria Rosaria Del Franci, Gianluigi Altucci, Carlo Eur Phys J Plus Regular Article We test the validity of a possible schematization of DNA structure and dynamics based on the Chern–Simons theory, that is a topological field theory mostly considered in the context of effective gravity theories. By means of the expectation value of the Wilson Loop, derived from this analogue gravity approach, we find the point-like curvature of genomic strings in KRAS human gene and COVID-19 sequences, correlating this curvature with the genetic mutations. The point-like curvature profile, obtained by means of the Chern–Simons currents, can be used to infer the position of the given mutations within the genetic string. Generally, mutations take place in the highest Chern–Simons current gradient locations and subsequent mutated sequences appear to have a smoother curvature than the initial ones, in agreement with a free energy minimization argument. Springer Berlin Heidelberg 2021-10-28 2021 /pmc/articles/PMC8551353/ /pubmed/34725629 http://dx.doi.org/10.1140/epjp/s13360-021-01960-5 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Regular Article Bajardi, Francesco Altucci, Lucia Benedetti, Rosaria Capozziello, Salvatore Sorbo, Maria Rosaria Del Franci, Gianluigi Altucci, Carlo DNA Mutations via Chern–Simons Currents |
title | DNA Mutations via Chern–Simons Currents |
title_full | DNA Mutations via Chern–Simons Currents |
title_fullStr | DNA Mutations via Chern–Simons Currents |
title_full_unstemmed | DNA Mutations via Chern–Simons Currents |
title_short | DNA Mutations via Chern–Simons Currents |
title_sort | dna mutations via chern–simons currents |
topic | Regular Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8551353/ https://www.ncbi.nlm.nih.gov/pubmed/34725629 http://dx.doi.org/10.1140/epjp/s13360-021-01960-5 |
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