The Value of Circulating Circular RNA in Cancer Diagnosis, Monitoring, Prognosis, and Guiding Treatment

Liquid biopsy includes non-invasive analysis of circulating tumor-derived substances. It is a novel, innovative cancer screening tool that overcomes the limitations of current invasive tissue examinations in precision oncology. Circular RNA (circRNA) is a recent, novel, and attractive liquid biomark...

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Detalles Bibliográficos
Autores principales: Zhang, Yunjing, Wang, Ying, Su, Xinwan, Wang, Ping, Lin, Weiqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8551378/
https://www.ncbi.nlm.nih.gov/pubmed/34722285
http://dx.doi.org/10.3389/fonc.2021.736546
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author Zhang, Yunjing
Wang, Ying
Su, Xinwan
Wang, Ping
Lin, Weiqiang
author_facet Zhang, Yunjing
Wang, Ying
Su, Xinwan
Wang, Ping
Lin, Weiqiang
author_sort Zhang, Yunjing
collection PubMed
description Liquid biopsy includes non-invasive analysis of circulating tumor-derived substances. It is a novel, innovative cancer screening tool that overcomes the limitations of current invasive tissue examinations in precision oncology. Circular RNA (circRNA) is a recent, novel, and attractive liquid biomarker showing stability, abundance, and high specificity in various diseases, especially in human cancers. This review focused on the emerging potential of human circRNA in body fluids as the liquid biopsy biomarkers for cancers and the methods used to detect the circRNA expression and summarized the construction of circRNA biomarkers in body fluids for treating human cancers and their limitations before they become part of routine clinical medicine. Furthermore, the future opportunities and challenges of translating circRNAs in liquid biopsy into clinical practices were explored.
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spelling pubmed-85513782021-10-29 The Value of Circulating Circular RNA in Cancer Diagnosis, Monitoring, Prognosis, and Guiding Treatment Zhang, Yunjing Wang, Ying Su, Xinwan Wang, Ping Lin, Weiqiang Front Oncol Oncology Liquid biopsy includes non-invasive analysis of circulating tumor-derived substances. It is a novel, innovative cancer screening tool that overcomes the limitations of current invasive tissue examinations in precision oncology. Circular RNA (circRNA) is a recent, novel, and attractive liquid biomarker showing stability, abundance, and high specificity in various diseases, especially in human cancers. This review focused on the emerging potential of human circRNA in body fluids as the liquid biopsy biomarkers for cancers and the methods used to detect the circRNA expression and summarized the construction of circRNA biomarkers in body fluids for treating human cancers and their limitations before they become part of routine clinical medicine. Furthermore, the future opportunities and challenges of translating circRNAs in liquid biopsy into clinical practices were explored. Frontiers Media S.A. 2021-10-14 /pmc/articles/PMC8551378/ /pubmed/34722285 http://dx.doi.org/10.3389/fonc.2021.736546 Text en Copyright © 2021 Zhang, Wang, Su, Wang and Lin https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Zhang, Yunjing
Wang, Ying
Su, Xinwan
Wang, Ping
Lin, Weiqiang
The Value of Circulating Circular RNA in Cancer Diagnosis, Monitoring, Prognosis, and Guiding Treatment
title The Value of Circulating Circular RNA in Cancer Diagnosis, Monitoring, Prognosis, and Guiding Treatment
title_full The Value of Circulating Circular RNA in Cancer Diagnosis, Monitoring, Prognosis, and Guiding Treatment
title_fullStr The Value of Circulating Circular RNA in Cancer Diagnosis, Monitoring, Prognosis, and Guiding Treatment
title_full_unstemmed The Value of Circulating Circular RNA in Cancer Diagnosis, Monitoring, Prognosis, and Guiding Treatment
title_short The Value of Circulating Circular RNA in Cancer Diagnosis, Monitoring, Prognosis, and Guiding Treatment
title_sort value of circulating circular rna in cancer diagnosis, monitoring, prognosis, and guiding treatment
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8551378/
https://www.ncbi.nlm.nih.gov/pubmed/34722285
http://dx.doi.org/10.3389/fonc.2021.736546
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