Thyroid Gene Mutations in Pregnant and Breastfeeding Women Diagnosed With Transient Congenital Hypothyroidism: Implications for the Offspring’s Health

Fetus and infants require appropriate thyroid hormone levels and iodine during pregnancy and lactation. Nature endorses the mother to supply thyroid hormones to the fetus and iodine to the lactating infant. Genetic variations on thyroid proteins that cause dyshormonogenic congenital hypothyroidism c...

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Autores principales: Opazo, Maria C., Rivera, Juan Carlos, Gonzalez, Pablo A., Bueno, Susan M., Kalergis, Alexis M., Riedel, Claudia A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Endocrinology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8551387/
https://www.ncbi.nlm.nih.gov/pubmed/34721286
http://dx.doi.org/10.3389/fendo.2021.679002
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author Opazo, Maria C.
Rivera, Juan Carlos
Gonzalez, Pablo A.
Bueno, Susan M.
Kalergis, Alexis M.
Riedel, Claudia A.
author_facet Opazo, Maria C.
Rivera, Juan Carlos
Gonzalez, Pablo A.
Bueno, Susan M.
Kalergis, Alexis M.
Riedel, Claudia A.
author_sort Opazo, Maria C.
collection PubMed
description Fetus and infants require appropriate thyroid hormone levels and iodine during pregnancy and lactation. Nature endorses the mother to supply thyroid hormones to the fetus and iodine to the lactating infant. Genetic variations on thyroid proteins that cause dyshormonogenic congenital hypothyroidism could in pregnant and breastfeeding women impair the delivery of thyroid hormones and iodine to the offspring. The review discusses maternal genetic variations in thyroid proteins that, in the context of pregnancy and/or breastfeeding, could trigger thyroid hormone deficiency or iodide transport defect that will affect the proper development of the offspring.
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spelling pubmed-85513872021-10-29 Thyroid Gene Mutations in Pregnant and Breastfeeding Women Diagnosed With Transient Congenital Hypothyroidism: Implications for the Offspring’s Health Opazo, Maria C. Rivera, Juan Carlos Gonzalez, Pablo A. Bueno, Susan M. Kalergis, Alexis M. Riedel, Claudia A. Front Endocrinol (Lausanne) Endocrinology Fetus and infants require appropriate thyroid hormone levels and iodine during pregnancy and lactation. Nature endorses the mother to supply thyroid hormones to the fetus and iodine to the lactating infant. Genetic variations on thyroid proteins that cause dyshormonogenic congenital hypothyroidism could in pregnant and breastfeeding women impair the delivery of thyroid hormones and iodine to the offspring. The review discusses maternal genetic variations in thyroid proteins that, in the context of pregnancy and/or breastfeeding, could trigger thyroid hormone deficiency or iodide transport defect that will affect the proper development of the offspring. Frontiers Media S.A. 2021-10-14 /pmc/articles/PMC8551387/ /pubmed/34721286 http://dx.doi.org/10.3389/fendo.2021.679002 Text en Copyright © 2021 Opazo, Rivera, Gonzalez, Bueno, Kalergis and Riedel https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Opazo, Maria C.
Rivera, Juan Carlos
Gonzalez, Pablo A.
Bueno, Susan M.
Kalergis, Alexis M.
Riedel, Claudia A.
Thyroid Gene Mutations in Pregnant and Breastfeeding Women Diagnosed With Transient Congenital Hypothyroidism: Implications for the Offspring’s Health
title Thyroid Gene Mutations in Pregnant and Breastfeeding Women Diagnosed With Transient Congenital Hypothyroidism: Implications for the Offspring’s Health
title_full Thyroid Gene Mutations in Pregnant and Breastfeeding Women Diagnosed With Transient Congenital Hypothyroidism: Implications for the Offspring’s Health
title_fullStr Thyroid Gene Mutations in Pregnant and Breastfeeding Women Diagnosed With Transient Congenital Hypothyroidism: Implications for the Offspring’s Health
title_full_unstemmed Thyroid Gene Mutations in Pregnant and Breastfeeding Women Diagnosed With Transient Congenital Hypothyroidism: Implications for the Offspring’s Health
title_short Thyroid Gene Mutations in Pregnant and Breastfeeding Women Diagnosed With Transient Congenital Hypothyroidism: Implications for the Offspring’s Health
title_sort thyroid gene mutations in pregnant and breastfeeding women diagnosed with transient congenital hypothyroidism: implications for the offspring’s health
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8551387/
https://www.ncbi.nlm.nih.gov/pubmed/34721286
http://dx.doi.org/10.3389/fendo.2021.679002
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