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Hypoxia-Induced Neuroinflammation in Alzheimer’s Disease: Potential Neuroprotective Effects of Centella asiatica

Alzheimer’s disease (AD) is a neurodegenerative disorder that is characterised by the presence of extracellular beta-amyloid fibrillary plaques and intraneuronal neurofibrillary tau tangles in the brain. Recurring failures of drug candidates targeting these pathways have prompted research in AD mult...

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Autores principales: Hambali, Aqilah, Kumar, Jaya, Hashim, Nur Fariesha Md, Maniam, Sandra, Mehat, Muhammad Zulfadli, Cheema, Manraj Singh, Mustapha, Muzaimi, Adenan, Mohd Ilham, Stanslas, Johnson, Hamid, Hafizah Abdul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8551388/
https://www.ncbi.nlm.nih.gov/pubmed/34721056
http://dx.doi.org/10.3389/fphys.2021.712317
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author Hambali, Aqilah
Kumar, Jaya
Hashim, Nur Fariesha Md
Maniam, Sandra
Mehat, Muhammad Zulfadli
Cheema, Manraj Singh
Mustapha, Muzaimi
Adenan, Mohd Ilham
Stanslas, Johnson
Hamid, Hafizah Abdul
author_facet Hambali, Aqilah
Kumar, Jaya
Hashim, Nur Fariesha Md
Maniam, Sandra
Mehat, Muhammad Zulfadli
Cheema, Manraj Singh
Mustapha, Muzaimi
Adenan, Mohd Ilham
Stanslas, Johnson
Hamid, Hafizah Abdul
author_sort Hambali, Aqilah
collection PubMed
description Alzheimer’s disease (AD) is a neurodegenerative disorder that is characterised by the presence of extracellular beta-amyloid fibrillary plaques and intraneuronal neurofibrillary tau tangles in the brain. Recurring failures of drug candidates targeting these pathways have prompted research in AD multifactorial pathogenesis, including the role of neuroinflammation. Triggered by various factors, such as hypoxia, neuroinflammation is strongly linked to AD susceptibility and/or progression to dementia. Chronic hypoxia induces neuroinflammation by activating microglia, the resident immune cells in the brain, along with an increased in reactive oxygen species and pro-inflammatory cytokines, features that are common to many degenerative central nervous system (CNS) disorders. Hence, interests are emerging on therapeutic agents and plant derivatives for AD that target the hypoxia-neuroinflammation pathway. Centella asiatica is one of the natural products reported to show neuroprotective effects in various models of CNS diseases. Here, we review the complex hypoxia-induced neuroinflammation in the pathogenesis of AD and the potential application of Centella asiatica as a therapeutic agent in AD or dementia.
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spelling pubmed-85513882021-10-29 Hypoxia-Induced Neuroinflammation in Alzheimer’s Disease: Potential Neuroprotective Effects of Centella asiatica Hambali, Aqilah Kumar, Jaya Hashim, Nur Fariesha Md Maniam, Sandra Mehat, Muhammad Zulfadli Cheema, Manraj Singh Mustapha, Muzaimi Adenan, Mohd Ilham Stanslas, Johnson Hamid, Hafizah Abdul Front Physiol Physiology Alzheimer’s disease (AD) is a neurodegenerative disorder that is characterised by the presence of extracellular beta-amyloid fibrillary plaques and intraneuronal neurofibrillary tau tangles in the brain. Recurring failures of drug candidates targeting these pathways have prompted research in AD multifactorial pathogenesis, including the role of neuroinflammation. Triggered by various factors, such as hypoxia, neuroinflammation is strongly linked to AD susceptibility and/or progression to dementia. Chronic hypoxia induces neuroinflammation by activating microglia, the resident immune cells in the brain, along with an increased in reactive oxygen species and pro-inflammatory cytokines, features that are common to many degenerative central nervous system (CNS) disorders. Hence, interests are emerging on therapeutic agents and plant derivatives for AD that target the hypoxia-neuroinflammation pathway. Centella asiatica is one of the natural products reported to show neuroprotective effects in various models of CNS diseases. Here, we review the complex hypoxia-induced neuroinflammation in the pathogenesis of AD and the potential application of Centella asiatica as a therapeutic agent in AD or dementia. Frontiers Media S.A. 2021-10-14 /pmc/articles/PMC8551388/ /pubmed/34721056 http://dx.doi.org/10.3389/fphys.2021.712317 Text en Copyright © 2021 Hambali, Kumar, Hashim, Maniam, Mehat, Cheema, Mustapha, Adenan, Stanslas and Hamid. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Hambali, Aqilah
Kumar, Jaya
Hashim, Nur Fariesha Md
Maniam, Sandra
Mehat, Muhammad Zulfadli
Cheema, Manraj Singh
Mustapha, Muzaimi
Adenan, Mohd Ilham
Stanslas, Johnson
Hamid, Hafizah Abdul
Hypoxia-Induced Neuroinflammation in Alzheimer’s Disease: Potential Neuroprotective Effects of Centella asiatica
title Hypoxia-Induced Neuroinflammation in Alzheimer’s Disease: Potential Neuroprotective Effects of Centella asiatica
title_full Hypoxia-Induced Neuroinflammation in Alzheimer’s Disease: Potential Neuroprotective Effects of Centella asiatica
title_fullStr Hypoxia-Induced Neuroinflammation in Alzheimer’s Disease: Potential Neuroprotective Effects of Centella asiatica
title_full_unstemmed Hypoxia-Induced Neuroinflammation in Alzheimer’s Disease: Potential Neuroprotective Effects of Centella asiatica
title_short Hypoxia-Induced Neuroinflammation in Alzheimer’s Disease: Potential Neuroprotective Effects of Centella asiatica
title_sort hypoxia-induced neuroinflammation in alzheimer’s disease: potential neuroprotective effects of centella asiatica
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8551388/
https://www.ncbi.nlm.nih.gov/pubmed/34721056
http://dx.doi.org/10.3389/fphys.2021.712317
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