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Deterioration of pancreatic exocrine function in carbon ion radiotherapy for pancreatic cancer
BACKGROUND AND PURPOSE: In radiotherapy (RT) for pancreatic cancer, the pancreas is considered an important organ at risk. However, there are insufficient reports on pancreatic function deterioration after X-ray RT as organ at risk, and there are no reports on those after carbon ion (C-ion) RT. Here...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8551411/ https://www.ncbi.nlm.nih.gov/pubmed/34746451 http://dx.doi.org/10.1016/j.ctro.2021.09.007 |
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author | Shiba, Shintaro Miyasaka, Yuhei Okamoto, Masahiko Komatsu, Shuichiro Okazaki, Shohei Shibuya, Kei Ohno, Tatsuya |
author_facet | Shiba, Shintaro Miyasaka, Yuhei Okamoto, Masahiko Komatsu, Shuichiro Okazaki, Shohei Shibuya, Kei Ohno, Tatsuya |
author_sort | Shiba, Shintaro |
collection | PubMed |
description | BACKGROUND AND PURPOSE: In radiotherapy (RT) for pancreatic cancer, the pancreas is considered an important organ at risk. However, there are insufficient reports on pancreatic function deterioration after X-ray RT as organ at risk, and there are no reports on those after carbon ion (C-ion) RT. Here, we evaluated pancreatic exocrine insufficiency (PEI) after C-ion RT using dose-volume histogram (DVH) analysis. MATERIALS AND METHODS: Data were retrospectively collected from patients who had undergone C-ion RT for pancreatic cancer between July 2013 and June 2019. The prescribed C-ion doses were 55.2 Gy (relative biological effectiveness) in 12 fractions. Serum pancreatic amylase and lipase values were measured before and after C-ion RT. In DVH analysis, we assessed V(5Gy–50Gy) and V(<5)(Gy–50Gy) of pancreatic volume and analyzed whether these DVH parameters involved PEI. RESULTS: Thirty-three patients were included in the analysis. The median follow-up duration after the initiation of C-ion RT in these patients was 15.8 months (range, 4.3–64.8). During and after treatment, 57.6% of patients developed PEI within 13.6 months, defined as pancreatic amylase and lipase deficiencies. In DVH analysis, V(<5Gy) was the most effective factor for the PEI, and the cutoff value for developing PEI in V(<5Gy) was 4.57 cm(3). CONCLUSION: We showed that pancreatic exocrine function declined after C-ion RT for pancreatic cancer and that PEI was initiated early in the course of C-ion RT. Additionally, a low dose of DVH parameters, such as V(<5Gy), was a prognostic factor of PEI. |
format | Online Article Text |
id | pubmed-8551411 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-85514112021-11-04 Deterioration of pancreatic exocrine function in carbon ion radiotherapy for pancreatic cancer Shiba, Shintaro Miyasaka, Yuhei Okamoto, Masahiko Komatsu, Shuichiro Okazaki, Shohei Shibuya, Kei Ohno, Tatsuya Clin Transl Radiat Oncol Article BACKGROUND AND PURPOSE: In radiotherapy (RT) for pancreatic cancer, the pancreas is considered an important organ at risk. However, there are insufficient reports on pancreatic function deterioration after X-ray RT as organ at risk, and there are no reports on those after carbon ion (C-ion) RT. Here, we evaluated pancreatic exocrine insufficiency (PEI) after C-ion RT using dose-volume histogram (DVH) analysis. MATERIALS AND METHODS: Data were retrospectively collected from patients who had undergone C-ion RT for pancreatic cancer between July 2013 and June 2019. The prescribed C-ion doses were 55.2 Gy (relative biological effectiveness) in 12 fractions. Serum pancreatic amylase and lipase values were measured before and after C-ion RT. In DVH analysis, we assessed V(5Gy–50Gy) and V(<5)(Gy–50Gy) of pancreatic volume and analyzed whether these DVH parameters involved PEI. RESULTS: Thirty-three patients were included in the analysis. The median follow-up duration after the initiation of C-ion RT in these patients was 15.8 months (range, 4.3–64.8). During and after treatment, 57.6% of patients developed PEI within 13.6 months, defined as pancreatic amylase and lipase deficiencies. In DVH analysis, V(<5Gy) was the most effective factor for the PEI, and the cutoff value for developing PEI in V(<5Gy) was 4.57 cm(3). CONCLUSION: We showed that pancreatic exocrine function declined after C-ion RT for pancreatic cancer and that PEI was initiated early in the course of C-ion RT. Additionally, a low dose of DVH parameters, such as V(<5Gy), was a prognostic factor of PEI. Elsevier 2021-10-03 /pmc/articles/PMC8551411/ /pubmed/34746451 http://dx.doi.org/10.1016/j.ctro.2021.09.007 Text en © 2021 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Article Shiba, Shintaro Miyasaka, Yuhei Okamoto, Masahiko Komatsu, Shuichiro Okazaki, Shohei Shibuya, Kei Ohno, Tatsuya Deterioration of pancreatic exocrine function in carbon ion radiotherapy for pancreatic cancer |
title | Deterioration of pancreatic exocrine function in carbon ion radiotherapy for pancreatic cancer |
title_full | Deterioration of pancreatic exocrine function in carbon ion radiotherapy for pancreatic cancer |
title_fullStr | Deterioration of pancreatic exocrine function in carbon ion radiotherapy for pancreatic cancer |
title_full_unstemmed | Deterioration of pancreatic exocrine function in carbon ion radiotherapy for pancreatic cancer |
title_short | Deterioration of pancreatic exocrine function in carbon ion radiotherapy for pancreatic cancer |
title_sort | deterioration of pancreatic exocrine function in carbon ion radiotherapy for pancreatic cancer |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8551411/ https://www.ncbi.nlm.nih.gov/pubmed/34746451 http://dx.doi.org/10.1016/j.ctro.2021.09.007 |
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