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Purification of full-length recombinant human huntingtin proteins with allelic series of polyglutamine lengths

Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder caused by the polyglutamine (polyQ) expansion in huntingtin (HTT) protein. The challenge of obtaining full-length HTT proteins with high purity limits the understanding of the HTT protein function. Here, we provide a...

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Detalles Bibliográficos
Autores principales:	Kim, Hyeongju, Hyun, Kyung-gi, Lloret, Alejandro, Seong, Ihn Sik, Song, Ji-Joon
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2021
Materias:	Protocol
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8551504/ https://www.ncbi.nlm.nih.gov/pubmed/34746859 http://dx.doi.org/10.1016/j.xpro.2021.100886

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