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Myricetin slows liquid–liquid phase separation of Tau and activates ATG5-dependent autophagy to suppress Tau toxicity

Intraneuronal neurofibrillary tangles composed of Tau aggregates have been widely accepted as an important pathological hallmark of Alzheimer's disease. A current therapeutic avenue for treating Alzheimer's disease is aimed at inhibiting Tau accumulation with small molecules such as natura...

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Detalles Bibliográficos
Autores principales:	Dai, Bin, Zhong, Tao, Chen, Zhi-Xian, Chen, Wang, Zhang, Na, Liu, Xiao-Ling, Wang, Li-Qiang, Chen, Jie, Liang, Yi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8551527/ https://www.ncbi.nlm.nih.gov/pubmed/34560101 http://dx.doi.org/10.1016/j.jbc.2021.101222

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