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Omega-3 versus Omega-6 fatty acid availability is controlled by hydrophobic site geometries of phospholipase A(2)s

Human phospholipase A(2)s (PLA(2)) constitute a superfamily of enzymes that hydrolyze the sn-2 acyl-chain of glycerophospholipids, producing lysophospholipids and free fatty acids. Each PLA(2) enzyme type contributes to specific biological functions based on its expression, subcellular localization,...

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Detalles Bibliográficos
Autores principales: Hayashi, Daiki, Mouchlis, Varnavas D., Dennis, Edward A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8551542/
https://www.ncbi.nlm.nih.gov/pubmed/34474084
http://dx.doi.org/10.1016/j.jlr.2021.100113

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