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Statin withdrawal and treating COVID‐19 patients

Most but not all observational studies of statin treatment of COVID‐19 patients suggest that treatment improves outcomes. However, almost all of these studies fail to consider that withdrawing statins after hospital admission may have detrimental effects, a finding which cardiovascular investigators...

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Autor principal: Fedson, David S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8551562/
https://www.ncbi.nlm.nih.gov/pubmed/34708573
http://dx.doi.org/10.1002/prp2.861
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author Fedson, David S.
author_facet Fedson, David S.
author_sort Fedson, David S.
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description Most but not all observational studies of statin treatment of COVID‐19 patients suggest that treatment improves outcomes. However, almost all of these studies fail to consider that withdrawing statins after hospital admission may have detrimental effects, a finding which cardiovascular investigators have known for 15–20 years. Continuing or starting statin treatment after hospital admission consistently improves cardiovascular outcomes. Similarly, inpatient statin treatment of COVID‐19 improves survival. For this reason, observational studies of the effectiveness of outpatient‐documented statin treatment of COVID‐19 patients must consider the negative consequences of statin withdrawal after hospital admission.
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spelling pubmed-85515622021-11-04 Statin withdrawal and treating COVID‐19 patients Fedson, David S. Pharmacol Res Perspect Short Report Most but not all observational studies of statin treatment of COVID‐19 patients suggest that treatment improves outcomes. However, almost all of these studies fail to consider that withdrawing statins after hospital admission may have detrimental effects, a finding which cardiovascular investigators have known for 15–20 years. Continuing or starting statin treatment after hospital admission consistently improves cardiovascular outcomes. Similarly, inpatient statin treatment of COVID‐19 improves survival. For this reason, observational studies of the effectiveness of outpatient‐documented statin treatment of COVID‐19 patients must consider the negative consequences of statin withdrawal after hospital admission. John Wiley and Sons Inc. 2021-10-27 /pmc/articles/PMC8551562/ /pubmed/34708573 http://dx.doi.org/10.1002/prp2.861 Text en © 2021 The Authors. Pharmacology Research & Perspectives published by John Wiley & Sons Ltd, British Pharmacological Society and American Society for Pharmacology and Experimental Therapeutics. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Short Report
Fedson, David S.
Statin withdrawal and treating COVID‐19 patients
title Statin withdrawal and treating COVID‐19 patients
title_full Statin withdrawal and treating COVID‐19 patients
title_fullStr Statin withdrawal and treating COVID‐19 patients
title_full_unstemmed Statin withdrawal and treating COVID‐19 patients
title_short Statin withdrawal and treating COVID‐19 patients
title_sort statin withdrawal and treating covid‐19 patients
topic Short Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8551562/
https://www.ncbi.nlm.nih.gov/pubmed/34708573
http://dx.doi.org/10.1002/prp2.861
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