Cargando…

Is Human Chorionic Gonadotropin Trigger Beneficial for Natural Cycle Frozen-Thawed Embryo Transfer?

Objective: The aim of this study is to investigate, in ovulatory patients, whether there is a difference in reproductive outcomes following frozen-thawed embryo transfer (FET) in natural cycles (NC) compared to modified natural cycles (mNC). Methods: This retrospective cohort study, performed at the...

Descripción completa

Detalles Bibliográficos
Autores principales: Gao, Dan-Dan, Li, Li, Zhang, Yi, Wang, Xiao-Xuan, Song, Jing-Yan, Sun, Zhen-Gao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8551612/
https://www.ncbi.nlm.nih.gov/pubmed/34722559
http://dx.doi.org/10.3389/fmed.2021.691428
_version_ 1784591197197565952
author Gao, Dan-Dan
Li, Li
Zhang, Yi
Wang, Xiao-Xuan
Song, Jing-Yan
Sun, Zhen-Gao
author_facet Gao, Dan-Dan
Li, Li
Zhang, Yi
Wang, Xiao-Xuan
Song, Jing-Yan
Sun, Zhen-Gao
author_sort Gao, Dan-Dan
collection PubMed
description Objective: The aim of this study is to investigate, in ovulatory patients, whether there is a difference in reproductive outcomes following frozen-thawed embryo transfer (FET) in natural cycles (NC) compared to modified natural cycles (mNC). Methods: This retrospective cohort study, performed at the public tertiary fertility clinic, involved all infertile patients undergoing endometrial preparation prior to FET in NC and mNC from January, 2017 to November, 2020. One thousand hundred and sixty-two patients were divided into two groups: mNC group (n = 248) had FET in a NC after ovulation triggering with human chorionic gonadotropin (hCG); NC group (n = 914) had FET in a NC after spontaneous ovulation were observed. The primary outcome was live birth rate. All pregnancy outcomes were analyzed by propensity score matching (PSM) and multivariable logistic regression analyses. Results: The NC group showed a higher live birth rate [344/914 (37.6%) vs. 68/248 (27.4%), P = 0.003; 87/240 (36.3%) vs. 66/240 (27.5%), P = 0.040] than the mNC group before and after PSM analysis. Multivariable analysis also showed mNC to be associated with a decreased likelihood of live birth compared with NC [odds ratio (OR) 95% confidence interval (CI) 0.71 (0.51–0.98), P = 0.039]. Conclusion: For women with regular menstrual cycles, NC-FET may have a higher chance of live birth than that in the mNC-FET cycles. As a consequence, it's critical to avoid hCG triggering as much as possible when FETs utilize a natural cycle strategy for endometrial preparation. Nevertheless, further more well-designed randomized clinical trials are still needed to determine this finding.
format Online
Article
Text
id pubmed-8551612
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-85516122021-10-29 Is Human Chorionic Gonadotropin Trigger Beneficial for Natural Cycle Frozen-Thawed Embryo Transfer? Gao, Dan-Dan Li, Li Zhang, Yi Wang, Xiao-Xuan Song, Jing-Yan Sun, Zhen-Gao Front Med (Lausanne) Medicine Objective: The aim of this study is to investigate, in ovulatory patients, whether there is a difference in reproductive outcomes following frozen-thawed embryo transfer (FET) in natural cycles (NC) compared to modified natural cycles (mNC). Methods: This retrospective cohort study, performed at the public tertiary fertility clinic, involved all infertile patients undergoing endometrial preparation prior to FET in NC and mNC from January, 2017 to November, 2020. One thousand hundred and sixty-two patients were divided into two groups: mNC group (n = 248) had FET in a NC after ovulation triggering with human chorionic gonadotropin (hCG); NC group (n = 914) had FET in a NC after spontaneous ovulation were observed. The primary outcome was live birth rate. All pregnancy outcomes were analyzed by propensity score matching (PSM) and multivariable logistic regression analyses. Results: The NC group showed a higher live birth rate [344/914 (37.6%) vs. 68/248 (27.4%), P = 0.003; 87/240 (36.3%) vs. 66/240 (27.5%), P = 0.040] than the mNC group before and after PSM analysis. Multivariable analysis also showed mNC to be associated with a decreased likelihood of live birth compared with NC [odds ratio (OR) 95% confidence interval (CI) 0.71 (0.51–0.98), P = 0.039]. Conclusion: For women with regular menstrual cycles, NC-FET may have a higher chance of live birth than that in the mNC-FET cycles. As a consequence, it's critical to avoid hCG triggering as much as possible when FETs utilize a natural cycle strategy for endometrial preparation. Nevertheless, further more well-designed randomized clinical trials are still needed to determine this finding. Frontiers Media S.A. 2021-10-14 /pmc/articles/PMC8551612/ /pubmed/34722559 http://dx.doi.org/10.3389/fmed.2021.691428 Text en Copyright © 2021 Gao, Li, Zhang, Wang, Song and Sun. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
Gao, Dan-Dan
Li, Li
Zhang, Yi
Wang, Xiao-Xuan
Song, Jing-Yan
Sun, Zhen-Gao
Is Human Chorionic Gonadotropin Trigger Beneficial for Natural Cycle Frozen-Thawed Embryo Transfer?
title Is Human Chorionic Gonadotropin Trigger Beneficial for Natural Cycle Frozen-Thawed Embryo Transfer?
title_full Is Human Chorionic Gonadotropin Trigger Beneficial for Natural Cycle Frozen-Thawed Embryo Transfer?
title_fullStr Is Human Chorionic Gonadotropin Trigger Beneficial for Natural Cycle Frozen-Thawed Embryo Transfer?
title_full_unstemmed Is Human Chorionic Gonadotropin Trigger Beneficial for Natural Cycle Frozen-Thawed Embryo Transfer?
title_short Is Human Chorionic Gonadotropin Trigger Beneficial for Natural Cycle Frozen-Thawed Embryo Transfer?
title_sort is human chorionic gonadotropin trigger beneficial for natural cycle frozen-thawed embryo transfer?
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8551612/
https://www.ncbi.nlm.nih.gov/pubmed/34722559
http://dx.doi.org/10.3389/fmed.2021.691428
work_keys_str_mv AT gaodandan ishumanchorionicgonadotropintriggerbeneficialfornaturalcyclefrozenthawedembryotransfer
AT lili ishumanchorionicgonadotropintriggerbeneficialfornaturalcyclefrozenthawedembryotransfer
AT zhangyi ishumanchorionicgonadotropintriggerbeneficialfornaturalcyclefrozenthawedembryotransfer
AT wangxiaoxuan ishumanchorionicgonadotropintriggerbeneficialfornaturalcyclefrozenthawedembryotransfer
AT songjingyan ishumanchorionicgonadotropintriggerbeneficialfornaturalcyclefrozenthawedembryotransfer
AT sunzhengao ishumanchorionicgonadotropintriggerbeneficialfornaturalcyclefrozenthawedembryotransfer