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Tyrosine phosphorylation of DEPTOR functions as a molecular switch to activate mTOR signaling

Metabolic dysfunction is a major driver of tumorigenesis. The serine/threonine kinase mechanistic target of rapamycin (mTOR) constitutes a key central regulator of metabolic pathways promoting cancer cell proliferation and survival. mTOR activity is regulated by metabolic sensors as well as by numer...

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Detalles Bibliográficos
Autores principales:	M. Gagné, Laurence, Morin, Nadine, Lavoie, Noémie, Bisson, Nicolas, Lambert, Jean-Philippe, Mallette, Frédérick A., Huot, Marc-Étienne
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8551655/ https://www.ncbi.nlm.nih.gov/pubmed/34634301 http://dx.doi.org/10.1016/j.jbc.2021.101291

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