Metabolic Profile in Neonatal Pig Hearts

We evaluated the metabolic profile in pig hearts at postnatal day 1, 3, 7, and 28 (P1, P3, P7, and P28, respectively) using a targeted liquid chromatography tandem mass spectrometry assay. Our data showed that there is a clear separation of the detected metabolites in P1 vs. P28 hearts. Active anabo...

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Autores principales: Li, Pengsheng, Li, Fan, Tang, Ling, Zhang, Wenjing, Jin, Yan, Gu, Haiwei, Zhu, Wuqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Cardiovascular Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8551694/
https://www.ncbi.nlm.nih.gov/pubmed/34722687
http://dx.doi.org/10.3389/fcvm.2021.763984
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author Li, Pengsheng
Li, Fan
Tang, Ling
Zhang, Wenjing
Jin, Yan
Gu, Haiwei
Zhu, Wuqiang
author_facet Li, Pengsheng
Li, Fan
Tang, Ling
Zhang, Wenjing
Jin, Yan
Gu, Haiwei
Zhu, Wuqiang
author_sort Li, Pengsheng
collection PubMed
description We evaluated the metabolic profile in pig hearts at postnatal day 1, 3, 7, and 28 (P1, P3, P7, and P28, respectively) using a targeted liquid chromatography tandem mass spectrometry assay. Our data showed that there is a clear separation of the detected metabolites in P1 vs. P28 hearts. Active anabolisms of nucleotide and proteins were observed in P1 hearts when cardiomyocytes retain high cell cycle activity. However, the active posttranslational protein modification, metabolic switch from glucose to fatty acids, and the reduced ratio of collagen to total protein were observed in P28 hearts when cardiomyocytes withdraw from cell cycle.
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spelling pubmed-85516942021-10-29 Metabolic Profile in Neonatal Pig Hearts Li, Pengsheng Li, Fan Tang, Ling Zhang, Wenjing Jin, Yan Gu, Haiwei Zhu, Wuqiang Front Cardiovasc Med Cardiovascular Medicine We evaluated the metabolic profile in pig hearts at postnatal day 1, 3, 7, and 28 (P1, P3, P7, and P28, respectively) using a targeted liquid chromatography tandem mass spectrometry assay. Our data showed that there is a clear separation of the detected metabolites in P1 vs. P28 hearts. Active anabolisms of nucleotide and proteins were observed in P1 hearts when cardiomyocytes retain high cell cycle activity. However, the active posttranslational protein modification, metabolic switch from glucose to fatty acids, and the reduced ratio of collagen to total protein were observed in P28 hearts when cardiomyocytes withdraw from cell cycle. Frontiers Media S.A. 2021-10-14 /pmc/articles/PMC8551694/ /pubmed/34722687 http://dx.doi.org/10.3389/fcvm.2021.763984 Text en Copyright © 2021 Li, Li, Tang, Zhang, Jin, Gu and Zhu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cardiovascular Medicine
Li, Pengsheng
Li, Fan
Tang, Ling
Zhang, Wenjing
Jin, Yan
Gu, Haiwei
Zhu, Wuqiang
Metabolic Profile in Neonatal Pig Hearts
title Metabolic Profile in Neonatal Pig Hearts
title_full Metabolic Profile in Neonatal Pig Hearts
title_fullStr Metabolic Profile in Neonatal Pig Hearts
title_full_unstemmed Metabolic Profile in Neonatal Pig Hearts
title_short Metabolic Profile in Neonatal Pig Hearts
title_sort metabolic profile in neonatal pig hearts
topic Cardiovascular Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8551694/
https://www.ncbi.nlm.nih.gov/pubmed/34722687
http://dx.doi.org/10.3389/fcvm.2021.763984
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AT zhangwenjing metabolicprofileinneonatalpighearts
AT jinyan metabolicprofileinneonatalpighearts
AT guhaiwei metabolicprofileinneonatalpighearts
AT zhuwuqiang metabolicprofileinneonatalpighearts

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