Inhibition of Rho Kinase by Fasudil Ameliorates Cognition Impairment in APP/PS1 Transgenic Mice via Modulation of Gut Microbiota and Metabolites

Background: Fasudil, a Rho kinase inhibitor, exerts therapeutic effects in a mouse model of Alzheimer's disease (AD), a chronic neurodegenerative disease with progressive loss of memory. However, the mechanisms remain unclear. In addition, the gut microbiota and its metabolites have been implic...

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Detalles Bibliográficos
Autores principales: Yan, Yuqing, Gao, Ye, Fang, Qingli, Zhang, Nianping, Kumar, Gajendra, Yan, Hailong, Song, Lijuan, Li, Jiehui, Zhang, Yuna, Sun, Jingxian, Wang, Jiawei, Zhao, Linhu, Skaggs, Keith, Zhang, Han-Ting, Ma, Cun-Gen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8551711/
https://www.ncbi.nlm.nih.gov/pubmed/34721000
http://dx.doi.org/10.3389/fnagi.2021.755164

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8551711/
https://www.ncbi.nlm.nih.gov/pubmed/34721000
http://dx.doi.org/10.3389/fnagi.2021.755164

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