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Hair Growth Promotion by δ-Opioid Receptor Activation
Literature has revealed that the delta opioid receptor (DOR) exhibited diverse pharmacological effects on neuron and skin. In the present study, we have investigated whether the activation of DOR has hair-growth promotion effects. Compared with other opioid receptor, DOR was highly expressed in epid...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Korean Society of Applied Pharmacology
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8551727/ https://www.ncbi.nlm.nih.gov/pubmed/34148869 http://dx.doi.org/10.4062/biomolther.2021.064 |
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author | Zheng, Mei Choi, Nahyun Balboni, Gianfranco Xia, Ying Sung, Jong-Hyuk |
author_facet | Zheng, Mei Choi, Nahyun Balboni, Gianfranco Xia, Ying Sung, Jong-Hyuk |
author_sort | Zheng, Mei |
collection | PubMed |
description | Literature has revealed that the delta opioid receptor (DOR) exhibited diverse pharmacological effects on neuron and skin. In the present study, we have investigated whether the activation of DOR has hair-growth promotion effects. Compared with other opioid receptor, DOR was highly expressed in epidermal component of hair follicle in human and rodents. The expression of DOR was high in the anagen phase, but it was low in the catagen and telogen phases during mouse hair cycle. Topical application of UFP-512, a specific DOR agonist, significantly accelerated the induction of the anagen in C(3)H mice. Topical application of UFP-512 also increased the hair length in hair organ cultures and promoted the proliferation and the migration of outer root sheath (ORS) cells. Similarly, pharmacological inhibition of DOR by naltrindole significantly inhibited the anagen transition process and decreased hair length in hair organ cultures. Thus, we further examined whether Wnt/β-catenin pathway was related to the effects of DOR on hair growth. We found that Wnt/β-catenin pathway was activated by UFP-512 and siRNA for β-catenin attenuated the UFP-512 induced proliferation and migration of ORS cells. Collectively, result established that DOR was involved in hair cycle regulation, and that DOR agonists such as UFP-512 should be developed for novel hair-loss treatment. |
format | Online Article Text |
id | pubmed-8551727 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | The Korean Society of Applied Pharmacology |
record_format | MEDLINE/PubMed |
spelling | pubmed-85517272021-10-31 Hair Growth Promotion by δ-Opioid Receptor Activation Zheng, Mei Choi, Nahyun Balboni, Gianfranco Xia, Ying Sung, Jong-Hyuk Biomol Ther (Seoul) Original Article Literature has revealed that the delta opioid receptor (DOR) exhibited diverse pharmacological effects on neuron and skin. In the present study, we have investigated whether the activation of DOR has hair-growth promotion effects. Compared with other opioid receptor, DOR was highly expressed in epidermal component of hair follicle in human and rodents. The expression of DOR was high in the anagen phase, but it was low in the catagen and telogen phases during mouse hair cycle. Topical application of UFP-512, a specific DOR agonist, significantly accelerated the induction of the anagen in C(3)H mice. Topical application of UFP-512 also increased the hair length in hair organ cultures and promoted the proliferation and the migration of outer root sheath (ORS) cells. Similarly, pharmacological inhibition of DOR by naltrindole significantly inhibited the anagen transition process and decreased hair length in hair organ cultures. Thus, we further examined whether Wnt/β-catenin pathway was related to the effects of DOR on hair growth. We found that Wnt/β-catenin pathway was activated by UFP-512 and siRNA for β-catenin attenuated the UFP-512 induced proliferation and migration of ORS cells. Collectively, result established that DOR was involved in hair cycle regulation, and that DOR agonists such as UFP-512 should be developed for novel hair-loss treatment. The Korean Society of Applied Pharmacology 2021-11-01 2021-06-21 /pmc/articles/PMC8551727/ /pubmed/34148869 http://dx.doi.org/10.4062/biomolther.2021.064 Text en Copyright © 2021, The Korean Society of Applied Pharmacology https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0 (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Zheng, Mei Choi, Nahyun Balboni, Gianfranco Xia, Ying Sung, Jong-Hyuk Hair Growth Promotion by δ-Opioid Receptor Activation |
title | Hair Growth Promotion by δ-Opioid Receptor Activation |
title_full | Hair Growth Promotion by δ-Opioid Receptor Activation |
title_fullStr | Hair Growth Promotion by δ-Opioid Receptor Activation |
title_full_unstemmed | Hair Growth Promotion by δ-Opioid Receptor Activation |
title_short | Hair Growth Promotion by δ-Opioid Receptor Activation |
title_sort | hair growth promotion by δ-opioid receptor activation |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8551727/ https://www.ncbi.nlm.nih.gov/pubmed/34148869 http://dx.doi.org/10.4062/biomolther.2021.064 |
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