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Brain MRI and neuropsychological findings at long-term follow-up after COVID-19 hospitalisation: an observational cohort study
OBJECTIVES: To report findings on brain MRI and neurocognitive function, as well as persisting fatigue at long-term follow-up after COVID-19 hospitalisation in patients identified as high risk for affection of the central nervous system. DESIGN: Ambidirectional observational cohort study. SETTING: A...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BMJ Publishing Group
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8551746/ https://www.ncbi.nlm.nih.gov/pubmed/34706965 http://dx.doi.org/10.1136/bmjopen-2021-055164 |
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author | Hellgren, Lovisa Birberg Thornberg, Ulrika Samuelsson, Kersti Levi, Richard Divanoglou, Anestis Blystad, Ida |
author_facet | Hellgren, Lovisa Birberg Thornberg, Ulrika Samuelsson, Kersti Levi, Richard Divanoglou, Anestis Blystad, Ida |
author_sort | Hellgren, Lovisa |
collection | PubMed |
description | OBJECTIVES: To report findings on brain MRI and neurocognitive function, as well as persisting fatigue at long-term follow-up after COVID-19 hospitalisation in patients identified as high risk for affection of the central nervous system. DESIGN: Ambidirectional observational cohort study. SETTING: All 734 patients from a regional population in Sweden with a laboratory-confirmed COVID-19 diagnosis admitted to hospital during the period 1 March to 31 May 2020. PARTICIPANTS: A subgroup (n=185) with persisting symptoms still interfering with daily life at a telephone follow-up 4 months after discharge were invited for a medical and neuropsychological evaluation. Thirty-five of those who were assessed with a neurocognitive test battery at the clinical visit, and presented a clinical picture concerning for COVID-19-related brain pathology, were further investigated by brain MRI. MAIN OUTCOME MEASURES: Findings on brain MRI, neurocognitive test results and reported fatigue. RESULTS: Twenty-five patients (71%) had abnormalities on MRI; multiple white matter lesions were the most common finding. Sixteen patients (46%) demonstrated impaired neurocognitive function, of which 10 (29%) had severe impairment. Twenty-six patients (74%) reported clinically significant fatigue. Patients with abnormalities on MRI had a lower Visuospatial Index (p=0.031) compared with the group with normal MRI findings. CONCLUSIONS: In this group of patients selected to undergo MRI after a clinical evaluation, a majority of patients had abnormal MRI and/or neurocognitive test results. Abnormal findings were not restricted to patients with severe disease. |
format | Online Article Text |
id | pubmed-8551746 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | BMJ Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-85517462021-10-28 Brain MRI and neuropsychological findings at long-term follow-up after COVID-19 hospitalisation: an observational cohort study Hellgren, Lovisa Birberg Thornberg, Ulrika Samuelsson, Kersti Levi, Richard Divanoglou, Anestis Blystad, Ida BMJ Open Infectious Diseases OBJECTIVES: To report findings on brain MRI and neurocognitive function, as well as persisting fatigue at long-term follow-up after COVID-19 hospitalisation in patients identified as high risk for affection of the central nervous system. DESIGN: Ambidirectional observational cohort study. SETTING: All 734 patients from a regional population in Sweden with a laboratory-confirmed COVID-19 diagnosis admitted to hospital during the period 1 March to 31 May 2020. PARTICIPANTS: A subgroup (n=185) with persisting symptoms still interfering with daily life at a telephone follow-up 4 months after discharge were invited for a medical and neuropsychological evaluation. Thirty-five of those who were assessed with a neurocognitive test battery at the clinical visit, and presented a clinical picture concerning for COVID-19-related brain pathology, were further investigated by brain MRI. MAIN OUTCOME MEASURES: Findings on brain MRI, neurocognitive test results and reported fatigue. RESULTS: Twenty-five patients (71%) had abnormalities on MRI; multiple white matter lesions were the most common finding. Sixteen patients (46%) demonstrated impaired neurocognitive function, of which 10 (29%) had severe impairment. Twenty-six patients (74%) reported clinically significant fatigue. Patients with abnormalities on MRI had a lower Visuospatial Index (p=0.031) compared with the group with normal MRI findings. CONCLUSIONS: In this group of patients selected to undergo MRI after a clinical evaluation, a majority of patients had abnormal MRI and/or neurocognitive test results. Abnormal findings were not restricted to patients with severe disease. BMJ Publishing Group 2021-10-27 /pmc/articles/PMC8551746/ /pubmed/34706965 http://dx.doi.org/10.1136/bmjopen-2021-055164 Text en © Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY. Published by BMJ. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Infectious Diseases Hellgren, Lovisa Birberg Thornberg, Ulrika Samuelsson, Kersti Levi, Richard Divanoglou, Anestis Blystad, Ida Brain MRI and neuropsychological findings at long-term follow-up after COVID-19 hospitalisation: an observational cohort study |
title | Brain MRI and neuropsychological findings at long-term follow-up after COVID-19 hospitalisation: an observational cohort study |
title_full | Brain MRI and neuropsychological findings at long-term follow-up after COVID-19 hospitalisation: an observational cohort study |
title_fullStr | Brain MRI and neuropsychological findings at long-term follow-up after COVID-19 hospitalisation: an observational cohort study |
title_full_unstemmed | Brain MRI and neuropsychological findings at long-term follow-up after COVID-19 hospitalisation: an observational cohort study |
title_short | Brain MRI and neuropsychological findings at long-term follow-up after COVID-19 hospitalisation: an observational cohort study |
title_sort | brain mri and neuropsychological findings at long-term follow-up after covid-19 hospitalisation: an observational cohort study |
topic | Infectious Diseases |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8551746/ https://www.ncbi.nlm.nih.gov/pubmed/34706965 http://dx.doi.org/10.1136/bmjopen-2021-055164 |
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