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Ectopic Splicing Disturbs the Function of Xist RNA to Establish the Stable Heterochromatin State
Non-coding Xist RNA plays an essential role in X chromosome inactivation (XCI) in female mammals. It coats the X chromosome in cis and mediates the recruitment of many proteins involved in gene silencing and heterochromatinization. The molecular basis of how Xist RNA initiates chromosomal silencing...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8551810/ https://www.ncbi.nlm.nih.gov/pubmed/34722536 http://dx.doi.org/10.3389/fcell.2021.751154 |