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Generation and validation of CRISPR-engineered human natural killer cell lines for research and therapeutic applications
Cytotoxic natural killer cells kill tumors and infected cells. We carried out CRISPR-based gene editing and transcriptional regulation in hard-to-manipulate NK-92 cells. NK-92-based therapies were found to be safe and efficacious in preclinical studies of cancers. Here, we have pioneered the generat...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8551845/ https://www.ncbi.nlm.nih.gov/pubmed/34746857 http://dx.doi.org/10.1016/j.xpro.2021.100874 |