Cargando…

A Humanized Mouse Strain That Develops Spontaneously Immune-Mediated Diabetes

To circumvent the limitations of available preclinical models for the study of type 1 diabetes (T1D), we developed a new humanized model, the YES-RIP-hB7.1 mouse. This mouse is deficient of murine major histocompatibility complex class I and class II, the murine insulin genes, and expresses as trans...

Descripción completa

Detalles Bibliográficos
Autores principales:	Luce, Sandrine, Guinoiseau, Sophie, Gadault, Alexis, Letourneur, Franck, Nitschke, Patrick, Bras, Marc, Vidaud, Michel, Charneau, Pierre, Larger, Etienne, Colli, Maikel L., Eizirik, Decio L., Lemonnier, François, Boitard, Christian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8551915/ https://www.ncbi.nlm.nih.gov/pubmed/34721418 http://dx.doi.org/10.3389/fimmu.2021.748679

Ejemplares similares

Molecular Footprints of the Immune Assault on Pancreatic Beta Cells in Type 1 Diabetes
por: Colli, Maikel L., et al.
Publicado: (2020)

Single Insulin-Specific CD8(+) T Cells Show Characteristic Gene Expression Profiles in Human Type 1 Diabetes
por: Luce, Sandrine, et al.
Publicado: (2011)

MDA5 and PTPN2, two candidate genes for type 1 diabetes, modify pancreatic β-cell responses to the viral by-product double-stranded RNA
por: Colli, Maikel L., et al.
Publicado: (2010)

Potential Role of IL-17-Producing iNKT Cells in Type 1 Diabetes
por: Li, Shamin, et al.
Publicado: (2014)

PTPN2, a Candidate Gene for Type 1 Diabetes, Modulates Pancreatic β-Cell Apoptosis via Regulation of the BH3-Only Protein Bim
por: Santin, Izortze, et al.
Publicado: (2011)

HLA-B7–Restricted Islet Epitopes Are Differentially Recognized in Type 1 Diabetic Children and Adults and Form Weak Peptide-HLA Complexes
por: Scotto, Matthieu, et al.
Publicado: (2012)

PTPN2, a Candidate Gene for Type 1 Diabetes, Modulates Interferon-γ–Induced Pancreatic β-Cell Apoptosis
por: Moore, Fabrice, et al.
Publicado: (2009)

Pro-Inflammatory Cytokines Promote the Transcription of Circular RNAs in Human Pancreatic β Cells
por: Kaur, Simranjeet, et al.
Publicado: (2022)

Preclinical Models to Evaluate the Human Response to Autoantigen and Antigen-Specific Immunotherapy in Human Type 1 Diabetes
por: Houeiss, Pamela, et al.
Publicado: (2022)

Environmental Triggering of Type 1 Diabetes Autoimmunity
por: Houeiss, Pamela, et al.
Publicado: (2022)

Exposure to the Viral By-Product dsRNA or Coxsackievirus B5 Triggers Pancreatic Beta Cell Apoptosis via a Bim / Mcl-1 Imbalance
por: Colli, Maikel L., et al.
Publicado: (2011)

Cytokines Interleukin-1β and Tumor Necrosis Factor-α Regulate Different Transcriptional and Alternative Splicing Networks in Primary β-Cells
por: Ortis, Fernanda, et al.
Publicado: (2010)

ADAR1-dependent editing regulates human β cell transcriptome diversity during inflammation
por: Szymczak, Florian, et al.
Publicado: (2022)

Diagnosing Diabetic Foot Osteomyelitis in Patients Without Signs of Soft Tissue Infection by Coupling Hybrid (67)Ga SPECT/CT With Bedside Percutaneous Bone Puncture
por: Aslangul, Elisabeth, et al.
Publicado: (2013)

GLIS3, a Susceptibility Gene for Type 1 and Type 2 Diabetes, Modulates Pancreatic Beta Cell Apoptosis via Regulation of a Splice Variant of the BH3-Only Protein Bim
por: Nogueira, Tatiane C., et al.
Publicado: (2013)

Recognition of Human Proinsulin Leader Sequence by Class I–Restricted T-Cells in HLA-A*0201 Transgenic Mice and in Human Type 1 Diabetes
por: Toma, Andréa, et al.
Publicado: (2009)

SARS-CoV-2 Receptor Angiotensin I-Converting Enzyme Type 2 (ACE2) Is Expressed in Human Pancreatic β-Cells and in the Human Pancreas Microvasculature
por: Fignani, Daniela, et al.
Publicado: (2020)

ER stress and the decline and fall of pancreatic beta cells in type 1 diabetes
por: Brozzi, Flora, et al.
Publicado: (2016)

The RNA-binding profile of the splicing factor SRSF6 in immortalized human pancreatic β-cells
por: Alvelos, Maria Inês, et al.
Publicado: (2020)

Transcription and splicing regulation by NLRC5 shape the interferon response in human pancreatic β cells
por: Szymczak, Florian, et al.
Publicado: (2022)

On the Immense Variety and Complexity of Circumstances Conditioning Pancreatic β-Cell Apoptosis in Type 1 Diabetes
por: Eizirik, Decio L., et al.
Publicado: (2012)

Checks and Balances—The Limits of β-Cell Endurance to ER Stress
por: Eizirik, Decio L., et al.
Publicado: (2017)

A functional genomic approach to identify reference genes for human pancreatic beta cell real-time quantitative RT-PCR analysis
por: Alvelos, Maria Inês, et al.
Publicado: (2021)

In silico identification of NF-kappaB-regulated genes in pancreatic beta-cells
por: Naamane, Najib, et al.
Publicado: (2007)

MAIT cell alterations in adults with recent-onset and long-term type 1 diabetes
por: Nel, Isabelle, et al.
Publicado: (2021)

The Human Pancreatic Islet Transcriptome: Expression of Candidate Genes for Type 1 Diabetes and the Impact of Pro-Inflammatory Cytokines
por: Eizirik, Décio L., et al.
Publicado: (2012)

From Pancreatic β-Cell Gene Networks to Novel Therapies for Type 1 Diabetes
por: Eizirik, Decio L., et al.
Publicado: (2021)

Beta Cell Imaging—From Pre-Clinical Validation to First in Man Testing
por: Demine, Stephane, et al.
Publicado: (2020)

Letters from Mars. Soft law under scrutiny of ethics during crisis. Responsibility and accountability: Serge Morard
por: Morard, S, et al.
Publicado: (2022)

Clic4, a novel protein that sensitizes β-cells to apoptosis()
por: Patel, Dhaval, et al.
Publicado: (2015)

JunB Inhibits ER Stress and Apoptosis in Pancreatic Beta Cells
por: Gurzov, Esteban N., et al.
Publicado: (2008)

Human alpha cell transcriptomic signatures of types 1 and 2 diabetes highlight disease-specific dysfunction pathways
por: Bosi, Emanuele, et al.
Publicado: (2022)

Endoplasmic reticulum stress sensitizes pancreatic beta cells to interleukin-1β-induced apoptosis via Bim/A1 imbalance
por: Miani, M, et al.
Publicado: (2013)

Gene expression signatures of target tissues in type 1 diabetes, lupus erythematosus, multiple sclerosis, and rheumatoid arthritis
por: Szymczak, F., et al.
Publicado: (2021)

PDL1 is expressed in the islets of people with type 1 diabetes and is up-regulated by interferons-α and-γ via IRF1 induction
por: Colli, Maikel L., et al.
Publicado: (2018)

The impact of pro-inflammatory cytokines on the β-cell regulatory landscape provides insights into the genetics of type 1 diabetes
por: Ramos-Rodríguez, Mireia, et al.
Publicado: (2019)

MCPIP1 regulates the sensitivity of pancreatic beta-cells to cytokine toxicity
por: Tyka, Karolina, et al.
Publicado: (2019)

Pro-inflammatory cytokines induce cell death, inflammatory responses, and endoplasmic reticulum stress in human iPSC-derived beta cells
por: Demine, Stéphane, et al.
Publicado: (2020)

The Pancreatic ß-cell Response to Secretory Demands and Adaption to Stress
por: Kalwat, Michael A, et al.
Publicado: (2021)

Angiopoietin 2 Alters Pancreatic Vascularization in Diabetic Conditions
por: Calderari, Sophie, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_si4fgfjfs1llikfgh5pgj5n28d