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Akkermansia muciniphila Protects Against Psychological Disorder-Induced Gut Microbiota-Mediated Colonic Mucosal Barrier Damage and Aggravation of Colitis

Psychological disorders are associated with increased risk of severe inflammatory bowel disease (IBD) by causing gut microbiota dysbiosis and colonic mucosal barrier damage. However, the interaction between chronic restraint stress (CRS), gut microbiota composition, and colonic mucus remains unclear...

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Autores principales: Chen, Tuo, Wang, Rong, Duan, Zhenglan, Yuan, Xiaomin, Ding, Yang, Feng, Zeyu, Bu, Fan, Liu, Li, Wang, Qiong, Zhou, Jinyong, Zhu, Lei, Ni, Qing, Shi, Guoping, Chen, Yugen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8551916/
https://www.ncbi.nlm.nih.gov/pubmed/34722332
http://dx.doi.org/10.3389/fcimb.2021.723856
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author Chen, Tuo
Wang, Rong
Duan, Zhenglan
Yuan, Xiaomin
Ding, Yang
Feng, Zeyu
Bu, Fan
Liu, Li
Wang, Qiong
Zhou, Jinyong
Zhu, Lei
Ni, Qing
Shi, Guoping
Chen, Yugen
author_facet Chen, Tuo
Wang, Rong
Duan, Zhenglan
Yuan, Xiaomin
Ding, Yang
Feng, Zeyu
Bu, Fan
Liu, Li
Wang, Qiong
Zhou, Jinyong
Zhu, Lei
Ni, Qing
Shi, Guoping
Chen, Yugen
author_sort Chen, Tuo
collection PubMed
description Psychological disorders are associated with increased risk of severe inflammatory bowel disease (IBD) by causing gut microbiota dysbiosis and colonic mucosal barrier damage. However, the interaction between chronic restraint stress (CRS), gut microbiota composition, and colonic mucus remains unclear. We demonstrated that mice under CRS conditions exhibited alterations in microbiota composition, disruption of colonic mucus, and aggravation of colitis. In addition, the abundance of Akkermansia muciniphila was significantly decreased in mice under CRS and UC patients with depression, and positively associated with the expression of MUC2. After antibiotic treatment, the recipient mice colonized with CRS microbiota showed barrier defects and severe colitis. Administration of Akkermansia muciniphila was found to restore colonic mucus and modify the gut microbiota. We confirm that CRS-mediated gut microbiota dysbiosis results in colonic mucosal barrier damage and aggravation of colitis. Our results suggest that A. muciniphila is expected to be a potential probiotic to protect and treat colonic mucus that is involved in IBD with psychological disorders.
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spelling pubmed-85519162021-10-29 Akkermansia muciniphila Protects Against Psychological Disorder-Induced Gut Microbiota-Mediated Colonic Mucosal Barrier Damage and Aggravation of Colitis Chen, Tuo Wang, Rong Duan, Zhenglan Yuan, Xiaomin Ding, Yang Feng, Zeyu Bu, Fan Liu, Li Wang, Qiong Zhou, Jinyong Zhu, Lei Ni, Qing Shi, Guoping Chen, Yugen Front Cell Infect Microbiol Cellular and Infection Microbiology Psychological disorders are associated with increased risk of severe inflammatory bowel disease (IBD) by causing gut microbiota dysbiosis and colonic mucosal barrier damage. However, the interaction between chronic restraint stress (CRS), gut microbiota composition, and colonic mucus remains unclear. We demonstrated that mice under CRS conditions exhibited alterations in microbiota composition, disruption of colonic mucus, and aggravation of colitis. In addition, the abundance of Akkermansia muciniphila was significantly decreased in mice under CRS and UC patients with depression, and positively associated with the expression of MUC2. After antibiotic treatment, the recipient mice colonized with CRS microbiota showed barrier defects and severe colitis. Administration of Akkermansia muciniphila was found to restore colonic mucus and modify the gut microbiota. We confirm that CRS-mediated gut microbiota dysbiosis results in colonic mucosal barrier damage and aggravation of colitis. Our results suggest that A. muciniphila is expected to be a potential probiotic to protect and treat colonic mucus that is involved in IBD with psychological disorders. Frontiers Media S.A. 2021-10-14 /pmc/articles/PMC8551916/ /pubmed/34722332 http://dx.doi.org/10.3389/fcimb.2021.723856 Text en Copyright © 2021 Chen, Wang, Duan, Yuan, Ding, Feng, Bu, Liu, Wang, Zhou, Zhu, Ni, Shi and Chen https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cellular and Infection Microbiology
Chen, Tuo
Wang, Rong
Duan, Zhenglan
Yuan, Xiaomin
Ding, Yang
Feng, Zeyu
Bu, Fan
Liu, Li
Wang, Qiong
Zhou, Jinyong
Zhu, Lei
Ni, Qing
Shi, Guoping
Chen, Yugen
Akkermansia muciniphila Protects Against Psychological Disorder-Induced Gut Microbiota-Mediated Colonic Mucosal Barrier Damage and Aggravation of Colitis
title Akkermansia muciniphila Protects Against Psychological Disorder-Induced Gut Microbiota-Mediated Colonic Mucosal Barrier Damage and Aggravation of Colitis
title_full Akkermansia muciniphila Protects Against Psychological Disorder-Induced Gut Microbiota-Mediated Colonic Mucosal Barrier Damage and Aggravation of Colitis
title_fullStr Akkermansia muciniphila Protects Against Psychological Disorder-Induced Gut Microbiota-Mediated Colonic Mucosal Barrier Damage and Aggravation of Colitis
title_full_unstemmed Akkermansia muciniphila Protects Against Psychological Disorder-Induced Gut Microbiota-Mediated Colonic Mucosal Barrier Damage and Aggravation of Colitis
title_short Akkermansia muciniphila Protects Against Psychological Disorder-Induced Gut Microbiota-Mediated Colonic Mucosal Barrier Damage and Aggravation of Colitis
title_sort akkermansia muciniphila protects against psychological disorder-induced gut microbiota-mediated colonic mucosal barrier damage and aggravation of colitis
topic Cellular and Infection Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8551916/
https://www.ncbi.nlm.nih.gov/pubmed/34722332
http://dx.doi.org/10.3389/fcimb.2021.723856
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