Integrated Genomic Profiling and Drug Screening of Patient-Derived Cultures Identifies Individualized Copy Number-Dependent Susceptibilities Involving PI3K Pathway and 17q Genes in Neuroblastoma

Neuroblastoma is the commonest extracranial pediatric malignancy. With few recurrent single nucleotide variations (SNVs), mutation-based precision oncology approaches have limited utility, but its frequent and heterogenous copy number variations (CNVs) could represent genomic dependencies that may b...

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Detalles Bibliográficos
Autores principales: Wong, Rachel L. Y., Wong, Megan R. E., Kuick, Chik Hong, Saffari, Seyed Ehsan, Wong, Meng Kang, Tan, Sheng Hui, Merchant, Khurshid, Chang, Kenneth T. E., Thangavelu, Matan, Periyasamy, Giridharan, Chen, Zhi Xiong, Iyer, Prasad, Tan, Enrica E. K., Soh, Shui Yen, Iyer, N. Gopalakrishna, Fan, Qiao, Loh, Amos H. P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8551924/
https://www.ncbi.nlm.nih.gov/pubmed/34722256
http://dx.doi.org/10.3389/fonc.2021.709525

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