Association between a 46-SNP Polygenic Risk Score and melanoma risk in Dutch patients with familial melanoma

BACKGROUND: Familial clustering of melanoma suggests a shared genetic predisposition among family members, but only 10%–40% of familial cases carry a pathogenic variant in a known high-risk melanoma susceptibility gene. We investigated whether a melanoma-specific Polygenic Risk Score (PRS) is associ...

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Detalles Bibliográficos
Autores principales: Potjer, Thomas P, van der Grinten, Tara W J, Lakeman, Inge M M, Bollen, Sander H, Rodríguez-Girondo, Mar, Iles, Mark M, Barrett, Jennifer H, Kiemeney, Lambertus A, Gruis, Nelleke A, van Asperen, Christi J, van der Stoep, Nienke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2021
Materias:
Cancer Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8551976/
https://www.ncbi.nlm.nih.gov/pubmed/32994281
http://dx.doi.org/10.1136/jmedgenet-2020-107251

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