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Clinical significance of golgi protein‐73 as a diagnostic marker for Egyptian patients with colorectal cancer: Preliminary study
BACKGROUND: Colorectal cancer is one of the most common cancers and the leading cause of cancer‐related death worldwide. Early diagnostic methods help in therapeutic success and higher survival rate. Golgi protein 73 (gp73) could help in diagnosis of colorectal cancer at an earlier stage. AIM: A cas...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8551982/ https://www.ncbi.nlm.nih.gov/pubmed/34014045 http://dx.doi.org/10.1002/cnr2.1379 |
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author | Abdelhady, Shaymaa Abdelraheem Attya, Heba Abdo, Mohamed Attia, Fadia M. |
author_facet | Abdelhady, Shaymaa Abdelraheem Attya, Heba Abdo, Mohamed Attia, Fadia M. |
author_sort | Abdelhady, Shaymaa Abdelraheem |
collection | PubMed |
description | BACKGROUND: Colorectal cancer is one of the most common cancers and the leading cause of cancer‐related death worldwide. Early diagnostic methods help in therapeutic success and higher survival rate. Golgi protein 73 (gp73) could help in diagnosis of colorectal cancer at an earlier stage. AIM: A case‐control study aimed to assess serum level of golgi protein 73 (gp73) as a liquid biopsy marker in Egyptian colorectal cancer patients. METHODS AND RESULTS: In the current study, ninty (90) patients were included and classified into three groups; thirty (30) patients with Colorectal cancer (CRC) as study group; 30 patients (20 patients with irritable bowel disease and 10 patients with rectal polyps) as pathological control and 30 healthy adult individuals as normal control. The diagnosis was based on the history, clinical, laboratory, endoscopic, and histological data. Golgiprotein 73 (GP73) was measured by ELISA immunoassay Kit. Serum GP73 level was higher in CRC patients than pathological control group and normal control group with high sensitivity and specificity p < .005. CONCLUSION: GP73 alone or combined with Carcinoembryonic antigen (CEA) may be good diagnositic marker in CRC. However large studies are warranted on different stages of the disease to assess its diagnostic and prognositic value. |
format | Online Article Text |
id | pubmed-8551982 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-85519822021-11-04 Clinical significance of golgi protein‐73 as a diagnostic marker for Egyptian patients with colorectal cancer: Preliminary study Abdelhady, Shaymaa Abdelraheem Attya, Heba Abdo, Mohamed Attia, Fadia M. Cancer Rep (Hoboken) Original Articles BACKGROUND: Colorectal cancer is one of the most common cancers and the leading cause of cancer‐related death worldwide. Early diagnostic methods help in therapeutic success and higher survival rate. Golgi protein 73 (gp73) could help in diagnosis of colorectal cancer at an earlier stage. AIM: A case‐control study aimed to assess serum level of golgi protein 73 (gp73) as a liquid biopsy marker in Egyptian colorectal cancer patients. METHODS AND RESULTS: In the current study, ninty (90) patients were included and classified into three groups; thirty (30) patients with Colorectal cancer (CRC) as study group; 30 patients (20 patients with irritable bowel disease and 10 patients with rectal polyps) as pathological control and 30 healthy adult individuals as normal control. The diagnosis was based on the history, clinical, laboratory, endoscopic, and histological data. Golgiprotein 73 (GP73) was measured by ELISA immunoassay Kit. Serum GP73 level was higher in CRC patients than pathological control group and normal control group with high sensitivity and specificity p < .005. CONCLUSION: GP73 alone or combined with Carcinoembryonic antigen (CEA) may be good diagnositic marker in CRC. However large studies are warranted on different stages of the disease to assess its diagnostic and prognositic value. John Wiley and Sons Inc. 2021-05-20 /pmc/articles/PMC8551982/ /pubmed/34014045 http://dx.doi.org/10.1002/cnr2.1379 Text en © 2021 The Authors. Cancer Reports published by Wiley Periodicals LLC. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Articles Abdelhady, Shaymaa Abdelraheem Attya, Heba Abdo, Mohamed Attia, Fadia M. Clinical significance of golgi protein‐73 as a diagnostic marker for Egyptian patients with colorectal cancer: Preliminary study |
title | Clinical significance of golgi protein‐73 as a diagnostic marker for Egyptian patients with colorectal cancer: Preliminary study |
title_full | Clinical significance of golgi protein‐73 as a diagnostic marker for Egyptian patients with colorectal cancer: Preliminary study |
title_fullStr | Clinical significance of golgi protein‐73 as a diagnostic marker for Egyptian patients with colorectal cancer: Preliminary study |
title_full_unstemmed | Clinical significance of golgi protein‐73 as a diagnostic marker for Egyptian patients with colorectal cancer: Preliminary study |
title_short | Clinical significance of golgi protein‐73 as a diagnostic marker for Egyptian patients with colorectal cancer: Preliminary study |
title_sort | clinical significance of golgi protein‐73 as a diagnostic marker for egyptian patients with colorectal cancer: preliminary study |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8551982/ https://www.ncbi.nlm.nih.gov/pubmed/34014045 http://dx.doi.org/10.1002/cnr2.1379 |
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