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High CD8/CD33 ratio in peritoneal metastatic lesions is associated with favorable prognosis in gastric cancer

BACKGROUND: Tumor‐infiltrating lymphocytes (TILs) and other immune cells have been reported as a prognostic factor in several tumors, including gastric cancer, and they play an important role in antitumor effect at the primary site. There were few reports on the immune status in peritoneal metastati...

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Autores principales: Yamaguchi, Takahisa, Kinoshita, Jun, Saito, Hiroto, Shimada, Mari, Terai, Siro, Moriyama, Hideki, Okamoto, Koichi, Makino, Isamu, Nakamura, Keishi, Tajima, Hidehiro, Ninomiya, Itasu, Fushida, Sachio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8551992/
https://www.ncbi.nlm.nih.gov/pubmed/33793095
http://dx.doi.org/10.1002/cnr2.1389
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author Yamaguchi, Takahisa
Kinoshita, Jun
Saito, Hiroto
Shimada, Mari
Terai, Siro
Moriyama, Hideki
Okamoto, Koichi
Makino, Isamu
Nakamura, Keishi
Tajima, Hidehiro
Ninomiya, Itasu
Fushida, Sachio
author_facet Yamaguchi, Takahisa
Kinoshita, Jun
Saito, Hiroto
Shimada, Mari
Terai, Siro
Moriyama, Hideki
Okamoto, Koichi
Makino, Isamu
Nakamura, Keishi
Tajima, Hidehiro
Ninomiya, Itasu
Fushida, Sachio
author_sort Yamaguchi, Takahisa
collection PubMed
description BACKGROUND: Tumor‐infiltrating lymphocytes (TILs) and other immune cells have been reported as a prognostic factor in several tumors, including gastric cancer, and they play an important role in antitumor effect at the primary site. There were few reports on the immune status in peritoneal metastatic lesions for gastric cancer. AIMS: The aims of this study were to assess the prognostic significance of TILs (CD4, CD8, CD19, regulatory T cells [Tregs]), and myeloid‐derived suppressor cells (MDSCs) in peritoneal metastatic lesions. METHODS: We retrospectively investigated 60 patients for gastric cancer with peritoneal metastasis who were treated between 2009 and 2016 in our institute. Immunohistochemistry for CD4, CD8, CD19, FOXP3, and CD33 was performed in the peritoneal metastatic lesions. The absolute numbers of immune cells and ratios were evaluated, and the relationship between immune‐related marker and overall survival (OS) was investigated. RESULTS: A high infiltration of CD8(+) lymphocytes or high CD8/CD33 ratio was a better prognosis for OS in univariate analysis using all immunologic variables (P = .012, P = .001). In multivariate analysis for clinical and immunologic variables, high CD8/CD33 ratio was identified as an independent prognostic factor for OS (Hazard ratio: 0.291, 95% confidence interval: 0.126‐0.670, P = .004). CONCLUSION: High CD8/CD33 ratio and high infiltration of CD8(+) lymphocytes in peritoneal metastatic lesions were favorable prognoses for gastric cancer patients with peritoneal metastasis. It is necessary to modify the immune microenvironment result to increase the level of CD8(+) lymphocytes in the peritoneal metastatic lesions.
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spelling pubmed-85519922021-11-04 High CD8/CD33 ratio in peritoneal metastatic lesions is associated with favorable prognosis in gastric cancer Yamaguchi, Takahisa Kinoshita, Jun Saito, Hiroto Shimada, Mari Terai, Siro Moriyama, Hideki Okamoto, Koichi Makino, Isamu Nakamura, Keishi Tajima, Hidehiro Ninomiya, Itasu Fushida, Sachio Cancer Rep (Hoboken) Original Articles BACKGROUND: Tumor‐infiltrating lymphocytes (TILs) and other immune cells have been reported as a prognostic factor in several tumors, including gastric cancer, and they play an important role in antitumor effect at the primary site. There were few reports on the immune status in peritoneal metastatic lesions for gastric cancer. AIMS: The aims of this study were to assess the prognostic significance of TILs (CD4, CD8, CD19, regulatory T cells [Tregs]), and myeloid‐derived suppressor cells (MDSCs) in peritoneal metastatic lesions. METHODS: We retrospectively investigated 60 patients for gastric cancer with peritoneal metastasis who were treated between 2009 and 2016 in our institute. Immunohistochemistry for CD4, CD8, CD19, FOXP3, and CD33 was performed in the peritoneal metastatic lesions. The absolute numbers of immune cells and ratios were evaluated, and the relationship between immune‐related marker and overall survival (OS) was investigated. RESULTS: A high infiltration of CD8(+) lymphocytes or high CD8/CD33 ratio was a better prognosis for OS in univariate analysis using all immunologic variables (P = .012, P = .001). In multivariate analysis for clinical and immunologic variables, high CD8/CD33 ratio was identified as an independent prognostic factor for OS (Hazard ratio: 0.291, 95% confidence interval: 0.126‐0.670, P = .004). CONCLUSION: High CD8/CD33 ratio and high infiltration of CD8(+) lymphocytes in peritoneal metastatic lesions were favorable prognoses for gastric cancer patients with peritoneal metastasis. It is necessary to modify the immune microenvironment result to increase the level of CD8(+) lymphocytes in the peritoneal metastatic lesions. John Wiley and Sons Inc. 2021-04-01 /pmc/articles/PMC8551992/ /pubmed/33793095 http://dx.doi.org/10.1002/cnr2.1389 Text en © 2021 The Authors. Cancer Reports published by Wiley Periodicals LLC. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles
Yamaguchi, Takahisa
Kinoshita, Jun
Saito, Hiroto
Shimada, Mari
Terai, Siro
Moriyama, Hideki
Okamoto, Koichi
Makino, Isamu
Nakamura, Keishi
Tajima, Hidehiro
Ninomiya, Itasu
Fushida, Sachio
High CD8/CD33 ratio in peritoneal metastatic lesions is associated with favorable prognosis in gastric cancer
title High CD8/CD33 ratio in peritoneal metastatic lesions is associated with favorable prognosis in gastric cancer
title_full High CD8/CD33 ratio in peritoneal metastatic lesions is associated with favorable prognosis in gastric cancer
title_fullStr High CD8/CD33 ratio in peritoneal metastatic lesions is associated with favorable prognosis in gastric cancer
title_full_unstemmed High CD8/CD33 ratio in peritoneal metastatic lesions is associated with favorable prognosis in gastric cancer
title_short High CD8/CD33 ratio in peritoneal metastatic lesions is associated with favorable prognosis in gastric cancer
title_sort high cd8/cd33 ratio in peritoneal metastatic lesions is associated with favorable prognosis in gastric cancer
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8551992/
https://www.ncbi.nlm.nih.gov/pubmed/33793095
http://dx.doi.org/10.1002/cnr2.1389
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