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Dihydrotanshinone I Specifically Inhibits NLRP3 Inflammasome Activation and Protects Against Septic Shock In Vivo

The abnormal activation of the NLRP3 inflammasome is closely related to the occurrence and development of many inflammatory diseases. Targeting the NLRP3 inflammasome has been considered an efficient therapy to treat infections. We found that dihydrotanshinone I (DHT) specifically blocked the canoni...

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Detalles Bibliográficos
Autores principales:	Wei, Ziying, Zhan, Xiaoyan, Ding, Kaixin, Xu, Guang, Shi, Wei, Ren, Lutong, Fang, Zhie, Liu, Tingting, Hou, Xiaorong, Zhao, Jia, Li, Hui, Li, Jiayi, Li, Zhiyong, Li, Qiang, Lin, Li, Yang, Yan, Xiao, Xiaohe, Bai, Zhaofang, Cao, Junling
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8552015/ https://www.ncbi.nlm.nih.gov/pubmed/34721038 http://dx.doi.org/10.3389/fphar.2021.750815

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