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SYDE1 Acts as an Oncogene in Glioma and has Diagnostic and Prognostic Values

Objectives: Gliomas remain one of serious public health problems worldwide which demand further and deeper investigation. The aim of this study was to explore the association between synapse defective protein 1 homolog 1 (SYDE1) and gliomas via public database analysis and in vitro validation to det...

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Autores principales: Han, Zhenyuan, Zhuang, Xiaodong, Yang, Biao, Jin, Lihui, Hong, Pengjie, Xue, Junqing, Chen, Shunjie, Tian, Zhen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8552071/
https://www.ncbi.nlm.nih.gov/pubmed/34722629
http://dx.doi.org/10.3389/fmolb.2021.714203
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author Han, Zhenyuan
Zhuang, Xiaodong
Yang, Biao
Jin, Lihui
Hong, Pengjie
Xue, Junqing
Chen, Shunjie
Tian, Zhen
author_facet Han, Zhenyuan
Zhuang, Xiaodong
Yang, Biao
Jin, Lihui
Hong, Pengjie
Xue, Junqing
Chen, Shunjie
Tian, Zhen
author_sort Han, Zhenyuan
collection PubMed
description Objectives: Gliomas remain one of serious public health problems worldwide which demand further and deeper investigation. The aim of this study was to explore the association between synapse defective protein 1 homolog 1 (SYDE1) and gliomas via public database analysis and in vitro validation to determine the potential diagnostic and prognostic values. Methods and Results: Compared with healthy brain tissues, there was a significant increase in SYDE1 expression in glioma tissues. Additionally, SYDE1 exhibited higher expression levels in glioma patients with unfavorable clinicopathological factors. In vitro knockdown of SYDE1 in glioma cell lines A172 inhibited their migrative and invasive ability but not the proliferative ability. GO and KEGG pathway analysis of the top 100 genes coexpressed with SYDE1 showed enrichments of tumor-associated terms. Further bioinformatic analysis revealed that the SNHG16/hsa-miR-520e/SYDE1 axis might be involved in glioma development. Conclusions: SYDE1 is expressed at higher levels in gliomas than in healthy brains, and can promote metastasis and invasion but not proliferation of gliomas. Furthermore, SYDE1 has values in the diagnosis and prognosis prediction of gliomas.
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spelling pubmed-85520712021-10-29 SYDE1 Acts as an Oncogene in Glioma and has Diagnostic and Prognostic Values Han, Zhenyuan Zhuang, Xiaodong Yang, Biao Jin, Lihui Hong, Pengjie Xue, Junqing Chen, Shunjie Tian, Zhen Front Mol Biosci Molecular Biosciences Objectives: Gliomas remain one of serious public health problems worldwide which demand further and deeper investigation. The aim of this study was to explore the association between synapse defective protein 1 homolog 1 (SYDE1) and gliomas via public database analysis and in vitro validation to determine the potential diagnostic and prognostic values. Methods and Results: Compared with healthy brain tissues, there was a significant increase in SYDE1 expression in glioma tissues. Additionally, SYDE1 exhibited higher expression levels in glioma patients with unfavorable clinicopathological factors. In vitro knockdown of SYDE1 in glioma cell lines A172 inhibited their migrative and invasive ability but not the proliferative ability. GO and KEGG pathway analysis of the top 100 genes coexpressed with SYDE1 showed enrichments of tumor-associated terms. Further bioinformatic analysis revealed that the SNHG16/hsa-miR-520e/SYDE1 axis might be involved in glioma development. Conclusions: SYDE1 is expressed at higher levels in gliomas than in healthy brains, and can promote metastasis and invasion but not proliferation of gliomas. Furthermore, SYDE1 has values in the diagnosis and prognosis prediction of gliomas. Frontiers Media S.A. 2021-10-14 /pmc/articles/PMC8552071/ /pubmed/34722629 http://dx.doi.org/10.3389/fmolb.2021.714203 Text en Copyright © 2021 Han, Zhuang, Yang, Jin, Hong, Xue, Chen and Tian. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Molecular Biosciences
Han, Zhenyuan
Zhuang, Xiaodong
Yang, Biao
Jin, Lihui
Hong, Pengjie
Xue, Junqing
Chen, Shunjie
Tian, Zhen
SYDE1 Acts as an Oncogene in Glioma and has Diagnostic and Prognostic Values
title SYDE1 Acts as an Oncogene in Glioma and has Diagnostic and Prognostic Values
title_full SYDE1 Acts as an Oncogene in Glioma and has Diagnostic and Prognostic Values
title_fullStr SYDE1 Acts as an Oncogene in Glioma and has Diagnostic and Prognostic Values
title_full_unstemmed SYDE1 Acts as an Oncogene in Glioma and has Diagnostic and Prognostic Values
title_short SYDE1 Acts as an Oncogene in Glioma and has Diagnostic and Prognostic Values
title_sort syde1 acts as an oncogene in glioma and has diagnostic and prognostic values
topic Molecular Biosciences
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8552071/
https://www.ncbi.nlm.nih.gov/pubmed/34722629
http://dx.doi.org/10.3389/fmolb.2021.714203
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