4-1BB and optimized CD28 co-stimulation enhances function of human mono-specific and bi-specific third-generation CAR T cells

BACKGROUND: Co-stimulatory signals regulate the expansion, persistence, and function of chimeric antigen receptor (CAR) T cells. Most studies have focused on the co-stimulatory domains CD28 or 4-1BB. CAR T cell persistence is enhanced by 4-1BB co-stimulation leading to nuclear factor kappa B (NF-κB)...

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Detalles Bibliográficos
Autores principales: Roselli, Emiliano, Boucher, Justin C, Li, Gongbo, Kotani, Hiroshi, Spitler, Kristen, Reid, Kayla, Cervantes, Estelle V, Bulliard, Yannick, Tu, Nhan, Lee, Sae Bom, Yu, Bin, Locke, Frederick L, Davila, Marco L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2021
Materias:
Immune Cell Therapies and Immune Cell Engineering
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8552146/
https://www.ncbi.nlm.nih.gov/pubmed/34706886
http://dx.doi.org/10.1136/jitc-2021-003354

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8552146/
https://www.ncbi.nlm.nih.gov/pubmed/34706886
http://dx.doi.org/10.1136/jitc-2021-003354

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