Targeting late I(CaL) to close the window to ventricular arrhythmias

This commentary is on the paper by Angelini et al. Here, we set the original paper in the context of triggered arrhythmias, particularly early after depolarizations (EADs), emphasizing the importance of pharmacologically inhibiting late Ca(2+) current to prevent EADs without affecting myocardial con...

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Detalles Bibliográficos
Autores principales: Gonano, Luis A., Mattiazzi, Alicia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2021
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8552155/
https://www.ncbi.nlm.nih.gov/pubmed/34699586
http://dx.doi.org/10.1085/jgp.202113009
Descripción
Sumario:This commentary is on the paper by Angelini et al. Here, we set the original paper in the context of triggered arrhythmias, particularly early after depolarizations (EADs), emphasizing the importance of pharmacologically inhibiting late Ca(2+) current to prevent EADs without affecting myocardial contractility.

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