Targeting late I(CaL) to close the window to ventricular arrhythmias

This commentary is on the paper by Angelini et al. Here, we set the original paper in the context of triggered arrhythmias, particularly early after depolarizations (EADs), emphasizing the importance of pharmacologically inhibiting late Ca(2+) current to prevent EADs without affecting myocardial con...

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Detalles Bibliográficos
Autores principales: Gonano, Luis A., Mattiazzi, Alicia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2021
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8552155/
https://www.ncbi.nlm.nih.gov/pubmed/34699586
http://dx.doi.org/10.1085/jgp.202113009
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author Gonano, Luis A.
Mattiazzi, Alicia
author_facet Gonano, Luis A.
Mattiazzi, Alicia
author_sort Gonano, Luis A.
collection PubMed
description This commentary is on the paper by Angelini et al. Here, we set the original paper in the context of triggered arrhythmias, particularly early after depolarizations (EADs), emphasizing the importance of pharmacologically inhibiting late Ca(2+) current to prevent EADs without affecting myocardial contractility.
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spelling pubmed-85521552022-06-06 Targeting late I(CaL) to close the window to ventricular arrhythmias Gonano, Luis A. Mattiazzi, Alicia J Gen Physiol Commentary This commentary is on the paper by Angelini et al. Here, we set the original paper in the context of triggered arrhythmias, particularly early after depolarizations (EADs), emphasizing the importance of pharmacologically inhibiting late Ca(2+) current to prevent EADs without affecting myocardial contractility. Rockefeller University Press 2021-10-26 /pmc/articles/PMC8552155/ /pubmed/34699586 http://dx.doi.org/10.1085/jgp.202113009 Text en © 2021 Gonano and Mattiazzi https://creativecommons.org/licenses/by-nc-sa/4.0/http://www.rupress.org/terms/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Commentary
Gonano, Luis A.
Mattiazzi, Alicia
Targeting late I(CaL) to close the window to ventricular arrhythmias
title Targeting late I(CaL) to close the window to ventricular arrhythmias
title_full Targeting late I(CaL) to close the window to ventricular arrhythmias
title_fullStr Targeting late I(CaL) to close the window to ventricular arrhythmias
title_full_unstemmed Targeting late I(CaL) to close the window to ventricular arrhythmias
title_short Targeting late I(CaL) to close the window to ventricular arrhythmias
title_sort targeting late i(cal) to close the window to ventricular arrhythmias
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8552155/
https://www.ncbi.nlm.nih.gov/pubmed/34699586
http://dx.doi.org/10.1085/jgp.202113009
work_keys_str_mv AT gonanoluisa targetinglateicaltoclosethewindowtoventriculararrhythmias
AT mattiazzialicia targetinglateicaltoclosethewindowtoventriculararrhythmias

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