Mechanism of Action of N-Acyl and N-Alkoxy Fosmidomycin Analogs: Mono- and Bisubstrate Inhibition of IspC from Plasmodium falciparum, a Causative Agent of Malaria

[Image: see text] Malaria is a global health threat that requires immediate attention. Malaria is caused by the protozoan parasite Plasmodium, the most severe form of which is Plasmodium falciparum. The methylerythritol phosphate (MEP) pathway of isoprenoid biosynthesis is essential to the survival...

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Detalles Bibliográficos
Autores principales: Girma, Misgina B., Ball, Haley S., Wang, Xu, Brothers, Robert C., Jackson, Emily R., Meyers, Marvin J., Dowd, Cynthia S., Couch, Robin D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8552233/
https://www.ncbi.nlm.nih.gov/pubmed/34722963
http://dx.doi.org/10.1021/acsomega.1c01711

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8552233/
https://www.ncbi.nlm.nih.gov/pubmed/34722963
http://dx.doi.org/10.1021/acsomega.1c01711

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