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Further Investigation of Synaptic Vesicle Protein 2A (SV2A) Ligands Designed for Positron Emission Tomography and Single-Photon Emission Computed Tomography Imaging: Synthesis and Structure–Activity Relationship of Substituted Pyridinylmethyl-4-(3,5-difluorophenyl)pyrrolidin-2-ones
[Image: see text] A series of synaptic vesicle protein 2A (SV2A) ligands were synthesized to explore the structure–activity relationship and to help further investigate a hydrogen bonding pharmacophore hypothesis. Racemic SynVesT-1 was used as a lead compound to explore the replacement of the 3-meth...
Autores principales: | Pracitto, Richard, Wilcox, Kyle C., Lindemann, Marcel, Tong, Jie, Zheng, Chao, Li, Songye, Finnema, Sjoerd J., Huang, Yiyun, Cai, Zhengxin |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical Society
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8552234/ https://www.ncbi.nlm.nih.gov/pubmed/34722967 http://dx.doi.org/10.1021/acsomega.1c02433 |
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