Metabolic compensation activates pro-survival mTORC1 signaling upon 3-phosphoglycerate dehydrogenase inhibition in osteosarcoma

Osteosarcoma is the most common pediatric and adult primary malignant bone cancer. Curative regimens target the folate pathway, downstream of serine metabolism, with high-dose methotrexate. Here, the rate-limiting enzyme in the biosynthesis of serine from glucose, 3-phosphoglycerate dehydrogenase (P...

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Detalles Bibliográficos
Autores principales: Rathore, Richa, Caldwell, Katharine E., Schutt, Charles, Brashears, Caitlyn B., Prudner, Bethany C., Ehrhardt, William R., Leung, Cheuk Hong, Lin, Heather, Daw, Najat C., Beird, Hannah C., Giles, Abigail, Wang, Wei-Lien, Lazar, Alexander J., Chrisinger, John S.A., Livingston, J. Andrew, Van Tine, Brian A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8552368/
https://www.ncbi.nlm.nih.gov/pubmed/33503424
http://dx.doi.org/10.1016/j.celrep.2020.108678

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