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NAD(+), Senolytics, or Pyruvate for Healthy Aging?

In last decades, healthy aging has become one of research hotspots in life science. It is well known that the nicotinamide adenine dinucleotide oxidized form (NAD(+)) level in cells decreases with aging and aging-related diseases. Several years ago, one of NAD(+) precursors was first demonstrated wi...

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Autor principal: Zhou, Fang-Qiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8552375/
https://www.ncbi.nlm.nih.gov/pubmed/34720589
http://dx.doi.org/10.1177/11786388211053407
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author Zhou, Fang-Qiang
author_facet Zhou, Fang-Qiang
author_sort Zhou, Fang-Qiang
collection PubMed
description In last decades, healthy aging has become one of research hotspots in life science. It is well known that the nicotinamide adenine dinucleotide oxidized form (NAD(+)) level in cells decreases with aging and aging-related diseases. Several years ago, one of NAD(+) precursors was first demonstrated with its new role in DNA damage repairing in mice, restoring old mice to their physical state at young ones. The finding encourages extensive studies in animal models and patients. NAD(+) and its precursors have been popular products in nutrition markets. Alternatively, it was also evidenced that clearance of cellular senescence by senolytics preserved multiorgan (kidney and heart) function and extended healthy lifespan in mice. Subsequent studies confirmed findings in elderly patients subjected with idiopathic pulmonary fibrosis. The senolytic therapy is now focused on various diseases in animal and clinical studies. However, pyruvate, as both a NAD(+) substitute and a new senolytic, may be advantageous, on the equimolar basis, over current products above in preventing and treating diseases and aging. Pyruvate-enriched fluids, particularly pyruvate oral rehydration salt, may be a novel intervention for diseases and aging besides critical care. Albeit the direct evidence that benefits healthy aging is still limited to date, pyruvate, as both NAD(+) provider and senolytic agent, warrants intensive research to compare NAD(+) or senolytics for healthy aging, specifically on the equimolar basis, in effective blood levels. This review briefly discussed the recognition of healthy aging by comparing NAD(+) and Senolytics with sodium pyruvate from the clinical point of view.
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spelling pubmed-85523752021-10-29 NAD(+), Senolytics, or Pyruvate for Healthy Aging? Zhou, Fang-Qiang Nutr Metab Insights Review In last decades, healthy aging has become one of research hotspots in life science. It is well known that the nicotinamide adenine dinucleotide oxidized form (NAD(+)) level in cells decreases with aging and aging-related diseases. Several years ago, one of NAD(+) precursors was first demonstrated with its new role in DNA damage repairing in mice, restoring old mice to their physical state at young ones. The finding encourages extensive studies in animal models and patients. NAD(+) and its precursors have been popular products in nutrition markets. Alternatively, it was also evidenced that clearance of cellular senescence by senolytics preserved multiorgan (kidney and heart) function and extended healthy lifespan in mice. Subsequent studies confirmed findings in elderly patients subjected with idiopathic pulmonary fibrosis. The senolytic therapy is now focused on various diseases in animal and clinical studies. However, pyruvate, as both a NAD(+) substitute and a new senolytic, may be advantageous, on the equimolar basis, over current products above in preventing and treating diseases and aging. Pyruvate-enriched fluids, particularly pyruvate oral rehydration salt, may be a novel intervention for diseases and aging besides critical care. Albeit the direct evidence that benefits healthy aging is still limited to date, pyruvate, as both NAD(+) provider and senolytic agent, warrants intensive research to compare NAD(+) or senolytics for healthy aging, specifically on the equimolar basis, in effective blood levels. This review briefly discussed the recognition of healthy aging by comparing NAD(+) and Senolytics with sodium pyruvate from the clinical point of view. SAGE Publications 2021-10-26 /pmc/articles/PMC8552375/ /pubmed/34720589 http://dx.doi.org/10.1177/11786388211053407 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Review
Zhou, Fang-Qiang
NAD(+), Senolytics, or Pyruvate for Healthy Aging?
title NAD(+), Senolytics, or Pyruvate for Healthy Aging?
title_full NAD(+), Senolytics, or Pyruvate for Healthy Aging?
title_fullStr NAD(+), Senolytics, or Pyruvate for Healthy Aging?
title_full_unstemmed NAD(+), Senolytics, or Pyruvate for Healthy Aging?
title_short NAD(+), Senolytics, or Pyruvate for Healthy Aging?
title_sort nad(+), senolytics, or pyruvate for healthy aging?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8552375/
https://www.ncbi.nlm.nih.gov/pubmed/34720589
http://dx.doi.org/10.1177/11786388211053407
work_keys_str_mv AT zhoufangqiang nadsenolyticsorpyruvateforhealthyaging