Potent and Subtype-Selective Dopamine D(2) Receptor Biased Partial Agonists Discovered via an Ugi-Based Approach

[Image: see text] Using a previously unexplored, efficient, and versatile multicomponent method, we herein report the rapid generation of novel potent and subtype-selective DRD(2) biased partial agonists. This strategy exemplifies the search for diverse and previously unexplored moieties for the sec...

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Detalles Bibliográficos
Autores principales: Mallo-Abreu, Ana, Reyes-Resina, Irene, Azuaje, Jhonny, Franco, Rafael, García-Rey, Aitor, Majellaro, Maria, Miranda-Pastoriza, Darío, García-Mera, Xerardo, Jespers, Willem, Gutiérrez-de-Terán, Hugo, Navarro, Gemma, Sotelo, Eddy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8552448/
https://www.ncbi.nlm.nih.gov/pubmed/34110150
http://dx.doi.org/10.1021/acs.jmedchem.1c00704

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