Chemically modified mRNA beyond COVID-19: Potential preventive and therapeutic applications for targeting chronic diseases

Chemically modified mRNA represents a unique, efficient, and straightforward approach to produce a class of biopharmaceutical agents. It has been already approved as a vaccination-based method for targeting SARS-CoV-2 virus. The COVID-19 pandemic has highlighted the prospect of synthetic modified mR...

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Detalles Bibliográficos
Autores principales: Elkhalifa, Dana, Rayan, Menatallah, Negmeldin, Ahmed T., Elhissi, Abdelbary, Khalil, Ashraf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Authors. Published by Elsevier Masson SAS. 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8552589/
https://www.ncbi.nlm.nih.gov/pubmed/34915673
http://dx.doi.org/10.1016/j.biopha.2021.112385
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author Elkhalifa, Dana
Rayan, Menatallah
Negmeldin, Ahmed T.
Elhissi, Abdelbary
Khalil, Ashraf
author_facet Elkhalifa, Dana
Rayan, Menatallah
Negmeldin, Ahmed T.
Elhissi, Abdelbary
Khalil, Ashraf
author_sort Elkhalifa, Dana
collection PubMed
description Chemically modified mRNA represents a unique, efficient, and straightforward approach to produce a class of biopharmaceutical agents. It has been already approved as a vaccination-based method for targeting SARS-CoV-2 virus. The COVID-19 pandemic has highlighted the prospect of synthetic modified mRNA to efficiently and safely combat various diseases. Recently, various optimization advances have been adopted to overcome the limitations associated with conventional gene therapeutics leading to wide-ranging applications in different disease conditions. This review sheds light on emerging directions of chemically modified mRNAs to prevent and treat widespread chronic diseases, including metabolic disorders, cancer vaccination and immunotherapy, musculoskeletal disorders, respiratory conditions, cardiovascular diseases, and liver diseases.
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spelling pubmed-85525892021-10-29 Chemically modified mRNA beyond COVID-19: Potential preventive and therapeutic applications for targeting chronic diseases Elkhalifa, Dana Rayan, Menatallah Negmeldin, Ahmed T. Elhissi, Abdelbary Khalil, Ashraf Biomed Pharmacother Review Chemically modified mRNA represents a unique, efficient, and straightforward approach to produce a class of biopharmaceutical agents. It has been already approved as a vaccination-based method for targeting SARS-CoV-2 virus. The COVID-19 pandemic has highlighted the prospect of synthetic modified mRNA to efficiently and safely combat various diseases. Recently, various optimization advances have been adopted to overcome the limitations associated with conventional gene therapeutics leading to wide-ranging applications in different disease conditions. This review sheds light on emerging directions of chemically modified mRNAs to prevent and treat widespread chronic diseases, including metabolic disorders, cancer vaccination and immunotherapy, musculoskeletal disorders, respiratory conditions, cardiovascular diseases, and liver diseases. The Authors. Published by Elsevier Masson SAS. 2022-01 2021-10-28 /pmc/articles/PMC8552589/ /pubmed/34915673 http://dx.doi.org/10.1016/j.biopha.2021.112385 Text en © 2021 The Authors Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Review
Elkhalifa, Dana
Rayan, Menatallah
Negmeldin, Ahmed T.
Elhissi, Abdelbary
Khalil, Ashraf
Chemically modified mRNA beyond COVID-19: Potential preventive and therapeutic applications for targeting chronic diseases
title Chemically modified mRNA beyond COVID-19: Potential preventive and therapeutic applications for targeting chronic diseases
title_full Chemically modified mRNA beyond COVID-19: Potential preventive and therapeutic applications for targeting chronic diseases
title_fullStr Chemically modified mRNA beyond COVID-19: Potential preventive and therapeutic applications for targeting chronic diseases
title_full_unstemmed Chemically modified mRNA beyond COVID-19: Potential preventive and therapeutic applications for targeting chronic diseases
title_short Chemically modified mRNA beyond COVID-19: Potential preventive and therapeutic applications for targeting chronic diseases
title_sort chemically modified mrna beyond covid-19: potential preventive and therapeutic applications for targeting chronic diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8552589/
https://www.ncbi.nlm.nih.gov/pubmed/34915673
http://dx.doi.org/10.1016/j.biopha.2021.112385
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