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From regenerative strategies to pharmacological approaches: can we fine-tune treatment for Parkinson's disease?

Parkinson's disease is the second most prevalent neurodegenerative disorder worldwide. Clinically, it is characterized by severe motor complications caused by progressive degeneration of dopaminergic neurons. Current treatment is focused on mitigating the symptoms through the administration of...

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Autores principales: Silva, Rita Caridade, Domingues, Helena Sofia, Salgado, António J., Teixeira, Fábio G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8552835/
https://www.ncbi.nlm.nih.gov/pubmed/34558504
http://dx.doi.org/10.4103/1673-5374.324827
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author Silva, Rita Caridade
Domingues, Helena Sofia
Salgado, António J.
Teixeira, Fábio G.
author_facet Silva, Rita Caridade
Domingues, Helena Sofia
Salgado, António J.
Teixeira, Fábio G.
author_sort Silva, Rita Caridade
collection PubMed
description Parkinson's disease is the second most prevalent neurodegenerative disorder worldwide. Clinically, it is characterized by severe motor complications caused by progressive degeneration of dopaminergic neurons. Current treatment is focused on mitigating the symptoms through the administration of levodopa, rather than on preventing dopaminergic neuronal damage. Therefore, the use and development of neuroprotective/disease-modifying strategies is an absolute need that can lead to promising gains on translational research of Parkinson's disease. For instance, N-acetylcysteine, a natural compound with strong antioxidant effects, has been shown to modulate oxidative stress, preventing dopamine-induced cell death. Despite the evidence of neuroprotective and modulatory effects of this drug, as far as we know, it does not induce per se any regenerative process. Therefore, it would be of interest to combine the latter with innovative therapies that induce dopaminergic neurons repair or even differentiation, as stem cell-based strategies. Stem cells secretome has been proposed as a promising therapeutic approach for Parkinson's disease, given its ability to modulate cell viability/preservation of dopaminergic neurons. Such approach represents a shift in the paradigm, showing that cell-transplantation free therapies based on the use of stem cells secretome may represent a potential alternative for regenerative medicine of Parkinson's disease. Thus, in this review, we address the current understanding of the potential combination of stem cell free-based strategies and neuroprotective/disease-modifying strategies as a new paradigm for the treatment of central nervous system neurodegenerative diseases, like Parkinson's disease.
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spelling pubmed-85528352021-11-09 From regenerative strategies to pharmacological approaches: can we fine-tune treatment for Parkinson's disease? Silva, Rita Caridade Domingues, Helena Sofia Salgado, António J. Teixeira, Fábio G. Neural Regen Res Review Parkinson's disease is the second most prevalent neurodegenerative disorder worldwide. Clinically, it is characterized by severe motor complications caused by progressive degeneration of dopaminergic neurons. Current treatment is focused on mitigating the symptoms through the administration of levodopa, rather than on preventing dopaminergic neuronal damage. Therefore, the use and development of neuroprotective/disease-modifying strategies is an absolute need that can lead to promising gains on translational research of Parkinson's disease. For instance, N-acetylcysteine, a natural compound with strong antioxidant effects, has been shown to modulate oxidative stress, preventing dopamine-induced cell death. Despite the evidence of neuroprotective and modulatory effects of this drug, as far as we know, it does not induce per se any regenerative process. Therefore, it would be of interest to combine the latter with innovative therapies that induce dopaminergic neurons repair or even differentiation, as stem cell-based strategies. Stem cells secretome has been proposed as a promising therapeutic approach for Parkinson's disease, given its ability to modulate cell viability/preservation of dopaminergic neurons. Such approach represents a shift in the paradigm, showing that cell-transplantation free therapies based on the use of stem cells secretome may represent a potential alternative for regenerative medicine of Parkinson's disease. Thus, in this review, we address the current understanding of the potential combination of stem cell free-based strategies and neuroprotective/disease-modifying strategies as a new paradigm for the treatment of central nervous system neurodegenerative diseases, like Parkinson's disease. Wolters Kluwer - Medknow 2021-09-17 /pmc/articles/PMC8552835/ /pubmed/34558504 http://dx.doi.org/10.4103/1673-5374.324827 Text en Copyright: © Neural Regeneration Research https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Review
Silva, Rita Caridade
Domingues, Helena Sofia
Salgado, António J.
Teixeira, Fábio G.
From regenerative strategies to pharmacological approaches: can we fine-tune treatment for Parkinson's disease?
title From regenerative strategies to pharmacological approaches: can we fine-tune treatment for Parkinson's disease?
title_full From regenerative strategies to pharmacological approaches: can we fine-tune treatment for Parkinson's disease?
title_fullStr From regenerative strategies to pharmacological approaches: can we fine-tune treatment for Parkinson's disease?
title_full_unstemmed From regenerative strategies to pharmacological approaches: can we fine-tune treatment for Parkinson's disease?
title_short From regenerative strategies to pharmacological approaches: can we fine-tune treatment for Parkinson's disease?
title_sort from regenerative strategies to pharmacological approaches: can we fine-tune treatment for parkinson's disease?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8552835/
https://www.ncbi.nlm.nih.gov/pubmed/34558504
http://dx.doi.org/10.4103/1673-5374.324827
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