Cargando…

Baicalin attenuates blood-spinal cord barrier disruption and apoptosis through PI3K/Akt signaling pathway after spinal cord injury

Baicalin is a natural active ingredient isolated from Scutellariae Radix that can cross the blood-brain barrier and exhibits neuroprotective effects on multiple central nervous system diseases. However, the mechanism behind the neuroprotective effects remains unclear. In this study, rat models of sp...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhao, Rui, Wu, Xue, Bi, Xue-Yuan, Yang, Hao, Zhang, Qian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Wolters Kluwer - Medknow 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8552841/ https://www.ncbi.nlm.nih.gov/pubmed/34558536 http://dx.doi.org/10.4103/1673-5374.324857

Ejemplares similares

Epidermal growth factor attenuates blood‐spinal cord barrier disruption via PI3K/Akt/Rac1 pathway after acute spinal cord injury
por: Zheng, Binbin, et al.
Publicado: (2016)

Ischemic Preconditioning Protects against Spinal Cord Ischemia-Reperfusion Injury in Rabbits by Attenuating Blood Spinal Cord Barrier Disruption
por: Fang, Bo, et al.
Publicado: (2013)

SIRT1 attenuates blood-spinal cord barrier disruption after spinal cord injury by deacetylating p66Shc
por: Jiang, Tao, et al.
Publicado: (2023)

Pathological hemodynamic changes and leukocyte transmigration disrupt the blood–spinal cord barrier after spinal cord injury
por: Zhou, Rubing, et al.
Publicado: (2023)

Blood-spinal cord barrier disruption in degenerative cervical myelopathy
por: Kim, Hyun Woo, et al.
Publicado: (2023)

CO-Releasing Molecule (CORM)-3 Ameliorates Spinal Cord-Blood Barrier Disruption Following Injury to the Spinal Cord
por: Zheng, Gang, et al.
Publicado: (2020)

Retinoic Acid Induced-Autophagic Flux Inhibits ER-Stress Dependent Apoptosis and Prevents Disruption of Blood-Spinal Cord Barrier after Spinal Cord Injury
por: Zhou, Yulong, et al.
Publicado: (2016)

The cross-talk between autophagy and endoplasmic reticulum stress in blood-spinal cord barrier disruption after spinal cord injury
por: Zhou, Yulong, et al.
Publicado: (2016)

Treadmill exercise reduces spinal cord injury-induced apoptosis by activating the PI3K/Akt pathway in rats
por: JUNG, SUN-YOUNG, et al.
Publicado: (2014)

Brilliant Blue G Inhibits Inflammasome Activation and Reduces Disruption of Blood–Spinal Cord Barrier Induced by Spinal Cord Injury in Rats
por: Zhou, Xin, et al.
Publicado: (2019)

Neutrophil Extracellular Traps Exacerbate Secondary Injury via Promoting Neuroinflammation and Blood–Spinal Cord Barrier Disruption in Spinal Cord Injury
por: Feng, Zhou, et al.
Publicado: (2021)

Water treadmill training attenuates blood-spinal cord barrier disruption in rats by promoting angiogenesis and inhibiting matrix metalloproteinase-2/9 expression following spinal cord injury
por: Ying, Xinwang, et al.
Publicado: (2020)

Small extracellular vesicles derived from umbilical cord mesenchymal stem cells repair blood-spinal cord barrier disruption after spinal cord injury through down-regulation of Endothelin-1 in rats
por: Xue, Chenhui, et al.
Publicado: (2023)

Spinal Cord Injury Causes Sustained Disruption of the Blood-Testis Barrier in the Rat
por: Dulin, Jennifer N., et al.
Publicado: (2011)

Experimental treatments to attenuate blood spinal cord barrier rupture in rats with traumatic spinal cord injury: A meta-analysis and systematic review
por: Deng, Li, et al.
Publicado: (2022)

Dl-3-n-butylphthalide prevents the disruption of blood-spinal cord barrier via inhibiting endoplasmic reticulum stress following spinal cord injury
por: Zheng, Binbin, et al.
Publicado: (2017)

Ferroptosis inhibition protects vascular endothelial cells and maintains integrity of the blood-spinal cord barrier after spinal cord injury
por: Li, Wenxiang, et al.
Publicado: (2023)

Moderate systemic therapeutic hypothermia is insufficient to protect blood-spinal cord barrier in spinal cord injury
por: Zhou, Rubing, et al.
Publicado: (2022)

Patchouli Alcohol Improves the Integrity of the Blood-Spinal Cord Barrier by Inhibiting Endoplasmic Reticulum Stress Through the Akt/CHOP/Caspase-3 Pathway Following Spinal Cord Injury
por: Huang, Chongan, et al.
Publicado: (2021)

Propofol protects against blood-spinal cord barrier disruption induced by ischemia/reperfusion injury
por: Xie, Li-jie, et al.
Publicado: (2017)

Effect of Spinal Shortening for Protection of Spinal Cord Function in Canines with Spinal Cord Angulation
por: Lu, Qiu-An, et al.
Publicado: (2019)

Effects of peripheral inflammation on the blood-spinal cord barrier
por: Xanthos, Dimitris N, et al.
Publicado: (2012)

Inflammation & apoptosis in spinal cord injury
por: Zhang, Ning, et al.
Publicado: (2012)

Delayed administration of nafamostat mesylate inhibits thrombin-mediated blood–spinal cord barrier breakdown during acute spinal cord injury in rats
por: Zhao, Chenxi, et al.
Publicado: (2022)

Astaxanthin protects spinal cord tissues from apoptosis after spinal cord injury in rats
por: Li, Shuang, et al.
Publicado: (2021)

Intranasal nerve growth factor bypasses the blood-brain barrier and affects spinal cord neurons in spinal cord injury
por: Aloe, Luigi, et al.
Publicado: (2014)

FGF23 alleviates neuronal apoptosis and inflammation, and promotes locomotion recovery via activation of PI3K/AKT signalling in spinal cord injury
por: Cui, Yan, et al.
Publicado: (2023)

Erxian decoction inhibits apoptosis by activating Akt1 and repairs spinal cord injury in rats
por: Li, Erliang, et al.
Publicado: (2022)

The Role of GABA in Spinal Cord Injury
por: Yao, Xue
Publicado: (2022)

Spinal Cord Injury in Rats Disrupts the Circadian System
por: Gaudet, Andrew D., et al.
Publicado: (2018)

The consequence of endothelial remodelling on the blood spinal cord barrier and nociception
por: Younis, Awais, et al.
Publicado: (2022)

Exosomes Derived From Pericytes Improve Microcirculation and Protect Blood–Spinal Cord Barrier After Spinal Cord Injury in Mice
por: Yuan, Xiaochen, et al.
Publicado: (2019)

Inhibition of Endoplasmic Reticulum Stress Preserves the Integrity of Blood-Spinal Cord Barrier in Diabetic Rats Subjected to Spinal Cord Injury
por: He, Zili, et al.
Publicado: (2017)

Icariin Inhibits Endoplasmic Reticulum Stress-induced Neuronal Apoptosis after Spinal Cord Injury through Modulating the PI3K/AKT Signaling Pathway
por: Li, Haotian, et al.
Publicado: (2019)

The Spinal Cord
por: Mauro, A.
Publicado: (1954)

Multifunctional biomimetic spinal cord: New approach to repair spinal cord injuries
por: Liu, Yang, et al.
Publicado: (2017)

Pannexin-1 Contributes to the Apoptosis of Spinal Neurocytes in Spinal Cord Injury
por: Huang, Yu, et al.
Publicado: (2021)

Evaluating regional blood spinal cord barrier dysfunction following spinal cord injury using longitudinal dynamic contrast-enhanced MRI
por: Tatar, Ilkan, et al.
Publicado: (2009)

Improved locomotor recovery after contusive spinal cord injury in Bmal1(−/−) mice is associated with protection of the blood spinal cord barrier
por: Slomnicki, Lukasz P., et al.
Publicado: (2020)

Olprinone Attenuates the Acute Inflammatory Response and Apoptosis after Spinal Cord Trauma in Mice
por: Esposito, Emanuela, et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_dcai66npoohn1n6eauqvi9c40g