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Percutaneous biopsy of small renal mass: can diagnostic accuracy be affected by hospital volume?
INTRODUCTION: High diagnostic performance and low morbidity for renal tumor biopsy (RTB) have been described in highly experienced centers. Here we present the five-year experience of our institute in performing RTB. The protocol used, the safety profile and the diagnostic accuracy obtained were ana...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Polish Urological Association
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8552940/ https://www.ncbi.nlm.nih.gov/pubmed/34729222 http://dx.doi.org/10.5173/ceju.2021.3.0104 |
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author | Ferrari, Matteo Cartolari, Roberto Barizzi, Jessica Pereira Mestre, Ricardo D’Antonio, Eugenia Renard, Julien |
author_facet | Ferrari, Matteo Cartolari, Roberto Barizzi, Jessica Pereira Mestre, Ricardo D’Antonio, Eugenia Renard, Julien |
author_sort | Ferrari, Matteo |
collection | PubMed |
description | INTRODUCTION: High diagnostic performance and low morbidity for renal tumor biopsy (RTB) have been described in highly experienced centers. Here we present the five-year experience of our institute in performing RTB. The protocol used, the safety profile and the diagnostic accuracy obtained were analyzed. MATERIAL AND METHODS: The study is a retrospective single-institution clinical data review of 84 consecutive RTB of small renal masses. Post-biopsy complications were reported using the Clavien-Dindo system. To measure the concordance between biopsy and nephrectomy specimens regarding histological subtype and International Society of Urological Pathology/World Health Organization (ISUP/WHO) renal cell carcinoma grade, the kappa coefficient of Cohen was used. RESULTS: Median (IQR) follow-up time was 44 (29–58) months. In total, 94% of RTB procedures were free of complications; when complications did occur, 80% were grade I and 20% were grade II. No cases of tumor seeding were observed. Combining the first and repeated biopsies the overall diagnostic rate was 85.8%. Overall, 79.1% of diagnostic RTB were malignant. In 42 surgically treated patients, the concordance between the histological results of biopsies and surgical specimens was very good for histological subtypes (k = 0.87) and moderate for tumor grade (k = 0.51). CONCLUSIONS: RTB resulted in a high safety profile. The overall diagnostic rate was 85% and an unnecessary intervention was avoided in 21% of patients. RTB showed a very good accuracy in determining the histological subtype of renal cancer while it was moderate for the tumor grade. These results are similar to those reported in larger series and support feasibility of this procedure in low-volume centers. |
format | Online Article Text |
id | pubmed-8552940 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Polish Urological Association |
record_format | MEDLINE/PubMed |
spelling | pubmed-85529402021-11-01 Percutaneous biopsy of small renal mass: can diagnostic accuracy be affected by hospital volume? Ferrari, Matteo Cartolari, Roberto Barizzi, Jessica Pereira Mestre, Ricardo D’Antonio, Eugenia Renard, Julien Cent European J Urol Original Paper INTRODUCTION: High diagnostic performance and low morbidity for renal tumor biopsy (RTB) have been described in highly experienced centers. Here we present the five-year experience of our institute in performing RTB. The protocol used, the safety profile and the diagnostic accuracy obtained were analyzed. MATERIAL AND METHODS: The study is a retrospective single-institution clinical data review of 84 consecutive RTB of small renal masses. Post-biopsy complications were reported using the Clavien-Dindo system. To measure the concordance between biopsy and nephrectomy specimens regarding histological subtype and International Society of Urological Pathology/World Health Organization (ISUP/WHO) renal cell carcinoma grade, the kappa coefficient of Cohen was used. RESULTS: Median (IQR) follow-up time was 44 (29–58) months. In total, 94% of RTB procedures were free of complications; when complications did occur, 80% were grade I and 20% were grade II. No cases of tumor seeding were observed. Combining the first and repeated biopsies the overall diagnostic rate was 85.8%. Overall, 79.1% of diagnostic RTB were malignant. In 42 surgically treated patients, the concordance between the histological results of biopsies and surgical specimens was very good for histological subtypes (k = 0.87) and moderate for tumor grade (k = 0.51). CONCLUSIONS: RTB resulted in a high safety profile. The overall diagnostic rate was 85% and an unnecessary intervention was avoided in 21% of patients. RTB showed a very good accuracy in determining the histological subtype of renal cancer while it was moderate for the tumor grade. These results are similar to those reported in larger series and support feasibility of this procedure in low-volume centers. Polish Urological Association 2021-07-07 2021 /pmc/articles/PMC8552940/ /pubmed/34729222 http://dx.doi.org/10.5173/ceju.2021.3.0104 Text en Copyright by Polish Urological Association https://creativecommons.org/licenses/by-nc-sa/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license. |
spellingShingle | Original Paper Ferrari, Matteo Cartolari, Roberto Barizzi, Jessica Pereira Mestre, Ricardo D’Antonio, Eugenia Renard, Julien Percutaneous biopsy of small renal mass: can diagnostic accuracy be affected by hospital volume? |
title | Percutaneous biopsy of small renal mass: can diagnostic accuracy be affected by hospital volume? |
title_full | Percutaneous biopsy of small renal mass: can diagnostic accuracy be affected by hospital volume? |
title_fullStr | Percutaneous biopsy of small renal mass: can diagnostic accuracy be affected by hospital volume? |
title_full_unstemmed | Percutaneous biopsy of small renal mass: can diagnostic accuracy be affected by hospital volume? |
title_short | Percutaneous biopsy of small renal mass: can diagnostic accuracy be affected by hospital volume? |
title_sort | percutaneous biopsy of small renal mass: can diagnostic accuracy be affected by hospital volume? |
topic | Original Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8552940/ https://www.ncbi.nlm.nih.gov/pubmed/34729222 http://dx.doi.org/10.5173/ceju.2021.3.0104 |
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