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Conditional Knockout of Pdha1 in Mouse Hippocampus Impairs Cognitive Function: The Possible Involvement of Lactate

Background and Purpose: Neurodegenerative diseases are associated with metabolic disturbances. Pyruvate dehydrogenase E1 component subunit alpha (PDHA1) is an essential component in the process of glucose metabolism, and its deficiency exists in various diseases such as Alzheimer’s disease (AD), epi...

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Detalles Bibliográficos
Autores principales:	Chen, Wanxin, Sun, Xiaoxia, Zhan, Libin, Zhou, Wen, Bi, Tingting
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8552971/ https://www.ncbi.nlm.nih.gov/pubmed/34720870 http://dx.doi.org/10.3389/fnins.2021.767560

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