6-Phosphogluconate dehydrogenase (6PGD), a key checkpoint in reprogramming of regulatory T cells metabolism and function

Cellular metabolism has key roles in T cells differentiation and function. CD4(+) T helper-1 (Th1), Th2, and Th17 subsets are highly glycolytic while regulatory T cells (Tregs) use glucose during expansion but rely on fatty acid oxidation for function. Upon uptake, glucose can enter pentose phosphat...

Descripción completa

Detalles Bibliográficos
Autores principales: Daneshmandi, Saeed, Cassel, Teresa, Higashi, Richard M, Fan, Teresa W-M, Seth, Pankaj
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8553335/
https://www.ncbi.nlm.nih.gov/pubmed/34709178
http://dx.doi.org/10.7554/eLife.67476

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8553335/
https://www.ncbi.nlm.nih.gov/pubmed/34709178
http://dx.doi.org/10.7554/eLife.67476

Ejemplares similares