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6-Phosphogluconate dehydrogenase (6PGD), a key checkpoint in reprogramming of regulatory T cells metabolism and function

Cellular metabolism has key roles in T cells differentiation and function. CD4(+) T helper-1 (Th1), Th2, and Th17 subsets are highly glycolytic while regulatory T cells (Tregs) use glucose during expansion but rely on fatty acid oxidation for function. Upon uptake, glucose can enter pentose phosphat...

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Detalles Bibliográficos
Autores principales:	Daneshmandi, Saeed, Cassel, Teresa, Higashi, Richard M, Fan, Teresa W-M, Seth, Pankaj
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2021
Materias:	Cell Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8553335/ https://www.ncbi.nlm.nih.gov/pubmed/34709178 http://dx.doi.org/10.7554/eLife.67476

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